Background: Leukocyte adhesion to arterial endothelial cells is thought to be an important step in the development of atherosclerosis, Adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1) and the endothelial-leukocyte adhesion molecule-1 (ELAM-1) play an essential role in the early stages of atherogenesis of diabetic patients. Materials and Methods: The study was conducted on 80 male divided into two groups 60 of them had diabetes mellitus and 20 subjects were normal healthy individuals served as a control group. Enzyme linked immune sorbent assay (ELISA) was used for the measurement of serum VCAM-1and ELAM-1and WBC assay executed by automatic hematology analyzer the information of patients were obtained through a questionnaire consisted Patients with other diseases were excluded from the current investigation. Results: This result revealed elevated level of serum VCAM-1and ELAM-1 of Diabetes patients compared with healthy group also differentiation count reveal elevated count of WBC, Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil in Diabetes patient as compare with HT group.
| Published in | American Journal of Life Sciences (Volume 3, Issue 1) |
| DOI | 10.11648/j.ajls.20150301.15 |
| Page(s) | 22-26 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2015. Published by Science Publishing Group |
ELAM-1, VCAM-1, NIDDM
| [1] | Krolewski A, Warram J, Valsania P, Martin B, Laffel L, Christlieb A. Evolving natural history of coronary artery disease in diabetes mellitus. Am. J. Med 1991; 90:56S-61S. |
| [2] | Factor S, Segal B, van Hoeven K. Diabetes and coronary vascular disease. Coron. Art. Dis 1991;3:4-10. |
| [3] | Nowak M1, Wielkoszyński T, Marek B, Kos-Kudła B, Swietochowska E, Siemińska L, et al. Blood serum levels of vascular cell adhesion molecule (sVCAM-1), intercellular adhesion molecule (sICAM-1) and endothelial leucocyte adhesion molecule-1 (ELAM-1) in diabetic retinopathy. Clin Exp Med 2008; 8(3):159-64. |
| [4] | Cybulsky M, Gimbrone M. Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis, Science. Wash. DC 1991;251:788-791. |
| [5] | Li H, Cybulsky M, Gimbrone M, Libby P.An atherogenic diet rapidly induces VCAM-1, a cytokine-regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium. Arterioscler. Thromb 1993;13:197-204.. |
| [6] | Richardson M, Hadcock S, DeReske M, Cybulsky M. Increased expression in vivo of VCAM-1 and E-selectin by the aortic endothelium of normolipemic and hyperlipemic diabetic rabbits. Arterioscler. Thromb 1994;14:760-769. |
| [7] | O’Brien KD, Allen MD, McDonald TO, Chait A, Harlan JM, Fishbein D, et al. Vascular cell adhesion molecule-1 is expressed in human coronary atherosclerotic plaques: implicationsfor the mode of progression of advanced coronary atherosclerosis, J ClinI n v e s t 1993;92:945–951. |
| [8] | Fasching P, Waldhausl W, Wagner O. Elevated circulating adhesion molecules in NIDDM; potential mediators in diabeticmacroangiopathy, Diabetologia 1996;39:1242-1244. |
| [9] | Albertini JP, Valensi P, Lormeau B,Aurousseau MH, Ferriere F, Attali JR,Gattegno L. Elevated concentrations ofsoluble E-selectin and vascular cell adhesion molecule-1 in NIDDM: effect of intensiveinsulin treatment.Diabetes Care 1998;21:1008–1013. |
| [10] | Kado S, Wakatsuki T, Yamamoto M, Nagata N. Expression of ICAM-1 induced by high glucose concentrations in human aortic endothelial cells. Life Sci 2001;68: 727-737. |
| [11] | Morigi M, Angioletti S, Imberti B, DonadelliR, Micheletti G, Figliuzzi M, et al.Leukocyte-endothelialinteraction is augmented by high glucoseconcentrations and hyperglycemia in aNF-kB-dependent fashion. J Clin Invest 1998;101:1905–1915. |
| [12] | Matsumoto K, Miyake S, Yano M, Ueki Y,Tominaga Y. High serum concentrationsof soluble E-selectin in patients with impairedglucose tolerance with hyperinsulinemia. Atherosclerosis 2000;152:415–420. |
| [13] | Yong Woo Lee, Paul H. Kim, Won Hee Lee, Anjali A. Interleukin-4, Oxidative Stress, Vascular Inflammation and Atherosclerosis. Biomol Ther 2010;18(2): 135–144. |
| [14] | Albelda SM, Smith CW, Ward PA. Adhesion molecules and inflammatory Injury, FASEB J 1994;8:504–512. |
| [15] | Springer TA. Adhesion receptors of the immune system, N a t u r e 1990;346 : 425 – 434. |
| [16] | O’Brien KD, McDonald TO, Chait A, Allen MD, Alpers CE. Neovascular expression of E-selectin, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in human atherosclerosis and their relation to intimal leukocyte content. C i r c u l a t i o n 1996;93:672–682. |
| [17] | Libby P, Li H. Vascular cell adhesion molecule-1 and smooth muscle cell activation during atherogenesis, J Clin Invest 1993;92:538–539. |
| [18] | Alon R, Kassner PD, Carr MW, Finger EB, Hemler ME, Springer TA. The integrin VLA-4 supports tethering and rolling in flow on VCAM-1, J Cell Biol 1995;128:1243–1253. |
| [19] | Luscinskas FW, Kansas GS, Ding H, Pizcueta P, Schleiffenbaum BE, Tedder TF, Gimbrone MA Jr. Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of L-selectin,beta 1-integrins, and beta 2-integrins, J Cell Biol 1994;125:1417–1427. |
| [20] | Jager A, van Hinsbergh VW, Kostense PJ, Emeis JJ, Nijpels G, Dekker JM, et al.Increased levels of soluble vascular cell adhesion molecule 1 are associated with risk of cardiovascular mortality in type 2 diabetes, the Hoorn study, Diabetes 2000;49(3):485-91. |
| [21] | Davies MJ, Gordon JL, Gearing AJ, Pigott R, Woolf N, Katz D, et al. The expression of the adhesion molecules ICAM-1, VCAM-1, PECAM, and E-selectin in human atherosclerosis, J Pathol 1993;171:223–229. |
| [22] | Gearing AJ, Hemingway I, Pigott R, Hughes J, Rees AJ, Cashman SJ. Soluble forms of vascular adhesion molecules, E-selectin, ICAM-1, and VCAM-1:pathological significance, Ann N Y Acad Sci 1992;667:324–331. |
| [23] | Gearing AJ, Newman W. Circulating adhesion molecules in disease, Immunol To d a y 1993;14:506–512. |
| [24] | Schmidt AM, Hori O, Chen JX, Li JF, Crandall J, Zhang J, et al. Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice: a potential mechanism for the accelerated vasculopathy of diabetes, J Clin Invest 1995;96:1395–1403. |
| [25] | Jang Y, Lincoff AM, Plow EF, Topol EJ. Cell adhesion molecules in coronary artery disease, J Am Coll C a r d i o l 1994; 24:1591–1601. |
| [26] | Kawamura T, Umemura T, Kanai A, Uno T, Matsumae H, Sano T, et al. The incidence and characteristics of silent cerebral infarction in elderly diabetic patients: association with serumsoluble adhesion molecules, D i a b e t o l o g i a 1998;41:911–917. |
| [27] | Elżbieta Pac-Kożuchowska. Evaluation of lipid parameters, homocysteine, adhesion molecules and carotid intima-media thickness in children from families with circulatory system diseases history,the journal of preventive medicine 2004;12 (3-4): 5-14 |
| [28] | De Caterina R, Basta G, Lazzerini G, Dell’Omo G, Petrucci R, Morale M, et al.Soluble vascular cell adhesion molecule-1 as a biohumoral correlate of atherosclerosis, Arterioscler Thromb Vasc Biol 1997;17 : 26 46–2654. |
| [29] | Peter K, Nawroth P, Conradt C, Nordt T, Weiss T, Boehme M, et al.Circulating vascular cell adhesion molecule-correlates with the extent of human atherosclerosis in contrast to circulat- ing intercellular adhesion molecule-1, E-selectin, P-selectin, and thrombomodulin, Arterioscler Thromb Vasc Biol 1997;17:505–512, 1997. |
| [30] | Farhan J Khawaja Iftikhar J Kullo. Novel markers of peripheral arterial disease, Vasc Med 2009;14(4): 381–392. |
| [31] | Shih-Jen Hwang, Christie M. Ballantyne, A. Richey Sharrett, Louis C. Smith, Clarence E. Davis, Antonio M. Gotto Jr, et al. Circulating Adhesion Molecules VCAM-1, ICAM-1, and E-selectin in Carotid Atherosclerosis and Incident Coronary Heart Disease Cases, Circulation 1997;96: 4219-4225. |
| [32] | Altannavch TS, Roubalova K, Kucera P, Andel M. Effect of High Glucose Concentrations on Expression of ELAM-1, VCAM-1 and ICAM-1 in HUVEC with and without Cytokine Activation, Physiol. Res 2004;53: 77-82, 2004 |
| [33] | Raja B Singh, Sushma A Mengi, Yan-Jun Xu, Amarjit S Arneja, Naranjan S Dhalla. Pathogenesis of atherosclerosis: A multifactorial process, Exp Clin Cardiol 2002;7(1): 40–53. |
| [34] | Mach F. The role of chemokines in atherosclerosis, Curr Atheroscler Rep 2001;3:243–51. |
| [35] | Elena Galkina, Klaus Ley.Vascular Adhesion Molecules in Atherosclerosis. Arteriosclerosis, Thrombosis and Vascular Biology 2007;27: 2292-2301. |
| [36] | Matsumoto K, Sera Y, Nakamura H, Ueki Y, Miyake S. Serum concentrations of soluble adhesion molecules are related to degree of hyperglycemia and insulin resistance in patients with type 2 diabetes mellitus, Diabetes Res Clin Pract 2002;55: 131-138. |
| [37] | Rizzoni D, Porteri E, Guelfi D, et al. Endothelial dysfunction in small resistance arteries of patients with non-insulin-de- pendent diabetes mellitus. J Hypertens 2001; 19: 913–919. |
| [38] | Kowalska I, Strączkowska M, Szelachowska M. Circu- lating E-selectin, vascular cell adhesion molecule-1, and in- tercellular adhesion molecule-1 in men with coronary artery disease assessed by angiography and disturbances of car- bohydrate metabolism, Metabolism 2002;51: 733–736. |
| [39] | Matsumoto K, Sera Y, Ueki Y Inukai G, Niiro E, Miyake S. Comparison of serum concentrations of soluble adhesion molecules in diabetic microangiopathy and macroangiopa- thy, Diabet Med 2002;19: 822–826. |
| [40] | Weissberg P. Mechanisms modifying atherosclerotic disease from lipids to vascular biology, Atherosclerosis 1999;147: 3–10. |
| [41] | Ewa R, Jolanta J, Bronisława S, Celina W, Krzysztof S, Łukasz S, etal. Evaluation of VCAM-1 and PAI-1 concentration in diabetes mellitus patients, Diabetologia Doświadczalna i Kliniczna 2008;8:85-88. |
| [42] | Ohshita K, Yamane K, Hanafusa M, Mori H, Mito K, Okubo M, etal. Elevated white blood cell count in sub- jects with impaired glucose tolerance, Di- abetes Care 2004;27:491–496. |
| [43] | Wei Xu1, Hai-feng Wu, Shao-gang Ma, Feng Bai, Wen Hu, Yue Jin, etal. Correlation between Peripheral White Blood Cell Counts and Hyperglycemic Emergencies, Int J Med Sci 2013;10(6):758-765. |
| [44] | Elyse D M, Stephen P G, Karin J D. Diabetes Alters Activation and Repression of Pro- and Anti-Inflammatory Signaling Pathways in the Vasculature, Front Endocrinol (Lausanne)2013;4: 68. |
| [45] | Ann Marie Schmidt, Osamu Hori, Jing Xian Chen, Jian Feng Li, Jill Crandall, Jinghua Zhang, etal.Advanced Glycation Endproducts Interacting with Their Endothelial Receptor Induce Expression of Vascular Cell Adhesion Molecule-1 (VCAM-1) in Cultured Human Endothelial Cells and in Mice, The Journal of Clinical Investigation 1995;96: 1395-1403. |
APA Style
Mohammed E. Al-Ghurabi, Ali A. Muhi, Dhefaf H. Al-Mudhafar. (2015). Vascular Cell Adhesion Molecule-1 and Endothelial Leukocyte Adhesion Molecule-1 as Markers of Atherosclerosis of NIDDM. American Journal of Life Sciences, 3(1), 22-26. https://doi.org/10.11648/j.ajls.20150301.15
ACS Style
Mohammed E. Al-Ghurabi; Ali A. Muhi; Dhefaf H. Al-Mudhafar. Vascular Cell Adhesion Molecule-1 and Endothelial Leukocyte Adhesion Molecule-1 as Markers of Atherosclerosis of NIDDM. Am. J. Life Sci. 2015, 3(1), 22-26. doi: 10.11648/j.ajls.20150301.15
AMA Style
Mohammed E. Al-Ghurabi, Ali A. Muhi, Dhefaf H. Al-Mudhafar. Vascular Cell Adhesion Molecule-1 and Endothelial Leukocyte Adhesion Molecule-1 as Markers of Atherosclerosis of NIDDM. Am J Life Sci. 2015;3(1):22-26. doi: 10.11648/j.ajls.20150301.15
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Download@article{10.11648/j.ajls.20150301.15,
author = {Mohammed E. Al-Ghurabi and Ali A. Muhi and Dhefaf H. Al-Mudhafar},
title = {Vascular Cell Adhesion Molecule-1 and Endothelial Leukocyte Adhesion Molecule-1 as Markers of Atherosclerosis of NIDDM},
journal = {American Journal of Life Sciences},
volume = {3},
number = {1},
pages = {22-26},
doi = {10.11648/j.ajls.20150301.15},
url = {https://doi.org/10.11648/j.ajls.20150301.15},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20150301.15},
abstract = {Background: Leukocyte adhesion to arterial endothelial cells is thought to be an important step in the development of atherosclerosis, Adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1) and the endothelial-leukocyte adhesion molecule-1 (ELAM-1) play an essential role in the early stages of atherogenesis of diabetic patients. Materials and Methods: The study was conducted on 80 male divided into two groups 60 of them had diabetes mellitus and 20 subjects were normal healthy individuals served as a control group. Enzyme linked immune sorbent assay (ELISA) was used for the measurement of serum VCAM-1and ELAM-1and WBC assay executed by automatic hematology analyzer the information of patients were obtained through a questionnaire consisted Patients with other diseases were excluded from the current investigation. Results: This result revealed elevated level of serum VCAM-1and ELAM-1 of Diabetes patients compared with healthy group also differentiation count reveal elevated count of WBC, Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil in Diabetes patient as compare with HT group.},
year = {2015}
}
TY - JOUR T1 - Vascular Cell Adhesion Molecule-1 and Endothelial Leukocyte Adhesion Molecule-1 as Markers of Atherosclerosis of NIDDM AU - Mohammed E. Al-Ghurabi AU - Ali A. Muhi AU - Dhefaf H. Al-Mudhafar Y1 - 2015/01/30 PY - 2015 N1 - https://doi.org/10.11648/j.ajls.20150301.15 DO - 10.11648/j.ajls.20150301.15 T2 - American Journal of Life Sciences JF - American Journal of Life Sciences JO - American Journal of Life Sciences SP - 22 EP - 26 PB - Science Publishing Group SN - 2328-5737 UR - https://doi.org/10.11648/j.ajls.20150301.15 AB - Background: Leukocyte adhesion to arterial endothelial cells is thought to be an important step in the development of atherosclerosis, Adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1) and the endothelial-leukocyte adhesion molecule-1 (ELAM-1) play an essential role in the early stages of atherogenesis of diabetic patients. Materials and Methods: The study was conducted on 80 male divided into two groups 60 of them had diabetes mellitus and 20 subjects were normal healthy individuals served as a control group. Enzyme linked immune sorbent assay (ELISA) was used for the measurement of serum VCAM-1and ELAM-1and WBC assay executed by automatic hematology analyzer the information of patients were obtained through a questionnaire consisted Patients with other diseases were excluded from the current investigation. Results: This result revealed elevated level of serum VCAM-1and ELAM-1 of Diabetes patients compared with healthy group also differentiation count reveal elevated count of WBC, Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil in Diabetes patient as compare with HT group. VL - 3 IS - 1 ER -
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