The Analysis Mutation of the CARD15 Gene Variants in Chronic Periodontitis

Asmawati Amin; Bahruddin Thalib; Mochammad Hatta

doi:doi:10.11648/j.ajcem.20140206.11

| Peer-Reviewed

The Analysis Mutation of the CARD15 Gene Variants in Chronic Periodontitis

Asmawati Amin, Bahruddin Thalib, Mochammad Hatta

Published in American Journal of Clinical and Experimental Medicine (Volume 2, Issue 6)

Received: 1 October 2014 Accepted: 17 October 2014 Published: 30 October 2014

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Purpose of this study was to determine the variant of CARD 15 gene mutations with periodontitis chronic .Identified by using polymerase chain reaction (PCR) and folowed by using restriction fragment length polymorphism analysis (RFLP). CARD 15 gene mutation with chronic periodontitis were found heterozygote mutation and homozygote mutation variants base on statistical analysis there were significant with control group ( p= 0,005) and also was founded genetics variation that changed the composition of C → T nucleotide at codon 802 in exon 4 amino acid, from alanine to valine.

Published in	American Journal of Clinical and Experimental Medicine (Volume 2, Issue 6)
DOI	10.11648/j.ajcem.20140206.11
Page(s)	117-122
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

CARD 15 Gene, Mutation, Chronic Periodontitis, Heterozygote, Homozygote

References

[1]	Darveau RP, Tanner A, Page RC. 2000. The microbial challenge in periodontitis kronis. Periodontol. 14: 13-25.
[2]	Slavkin HC, Baum BJ. 2000. Relationship of Dental and Oral pathology to systemic illness. JAMA.284;1215-1217.
[3]	Gazouli M, Mantzaris G, Kotsinas A et al. 2005. Association between polymorphisms in the toll-like receptor 4 ,CD14 and CARD15/NOD2 and inflamatory bowel disease in the greek population. Word J Gastroenterol 11(5):681-685
[4]	Leong RW, Armuzzi A, Ahmad T, et al. 2003. NOD2/CARD15 gene polymorphism and chron disesase in the chinese population, Aliment Pharmacol Ther,17:1465-1470
[5]	Haake SK, Nisengard RJ, Newmann MG, Miyasaki KT. 2002. Microbial interactions with the host in periodontal diseases. Dalam. Clinical Periodontology , 9th ed. W.B Saunders Co. Philadelphia, London, Toronto. 134 - 45.
[6]	Khoury MJ,Mc Cabe LL, Mc Cabe ER. Population screening in the age of genomic medicine, N Engl J Med 2003; 348; 50-8
[7]	Chamailard M, Girardin SE. An essential role for NOD1 in host recognition of bacterial peptideglycan containing diaminopimelic acid. Nat Imunol 2003; 4; 702-7
[8]	Girardin SE, Boneca IG et al. 2003. NOD 1 and NOD 2 detects a unique mucopeptida from gram negative bacterial peptidoglycan, science 300: 1584-1587
[9]	Fokkema SJ, Loos BG, de Sleege C, van de Velden U 2002 . A Type 2 response in LPS-stimulated whole blood cell cultures from periodontitis kronis patiens. Clin Exp Immunol, 127, 374-8.
[10]	Akira S, Takeda K. 2004. Toll like receptor signalling. Nat. Rev immunol 4: 499-511.
[11]	Fritz J.H, Ferrero, RI, Philpott, DJ. 2006. Signal tranduction pathways use by NLR type innate immune reseptors. http://www. Rsc. Org/ publishing/ journals/ MB/ article. Visited on 14 July 2008
[12]	Hatta.M and Smits HL. 2007. Detection of Salmonella typhi by nested polymerase Chain Reaction in blood, urine and stool samples. American J. Tropical Medicine Hygiene.vol : 76;139-143.
[13]	Haake SK, Nisengard RJ, Newmann MG, Miyasaki KT. 2002. Microbial interactions with the host in periodontal diseases. Dalam. Clinical Periodontology , 9th ed. W.B Saunders Co. Philadelphia, London, Toronto. 134 - 45.
[14]	Novak MJ. 2002. Classification of diseases and condition affecting the periodontium. Dalam. Clinical Periodontology , 9th ed. W.B Saunders Co. Philadelphia, London, Toronto. 64-72
[15]	Taize MNC, Maria C. 2006. Factors Related to Periodontal Disease in a Rural Population. Brazilian Oral Research. vol 20 no 3
[16]	Monteiro da Siva AM, Newman HN, Oeklay DA, O’ Leaary R. 1998. Psychosocial faktors, dental plaque levels and smoking in periodontitis kronis patients. J Clin Periodontol. .25 : 517-23
[17]	Noack B, Gorgens H, et al. 2006. CARD 15 / NOD 2 gene variants in aggressive periodontitis. J Clin Periodontol ;33:779-783
[18]	Hart TC, Kornman KS. 2000. Genetic faktors in the pathogenesis of periodontitis kronis. Periodontol. 1997; 14: 202-15

Cite This Article

Plain Text BibTeX RIS

APA Style

Asmawati Amin, Bahruddin Thalib, Mochammad Hatta. (2014). The Analysis Mutation of the CARD15 Gene Variants in Chronic Periodontitis. American Journal of Clinical and Experimental Medicine, 2(6), 117-122. https://doi.org/10.11648/j.ajcem.20140206.11

Copy | Download

ACS Style

Asmawati Amin; Bahruddin Thalib; Mochammad Hatta. The Analysis Mutation of the CARD15 Gene Variants in Chronic Periodontitis. Am. J. Clin. Exp. Med. 2014, 2(6), 117-122. doi: 10.11648/j.ajcem.20140206.11

Copy | Download

AMA Style

Asmawati Amin, Bahruddin Thalib, Mochammad Hatta. The Analysis Mutation of the CARD15 Gene Variants in Chronic Periodontitis. Am J Clin Exp Med. 2014;2(6):117-122. doi: 10.11648/j.ajcem.20140206.11

Copy | Download

@article{10.11648/j.ajcem.20140206.11,
  author = {Asmawati Amin and Bahruddin Thalib and Mochammad Hatta},
  title = {The Analysis Mutation of the CARD15 Gene Variants in Chronic Periodontitis},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {2},
  number = {6},
  pages = {117-122},
  doi = {10.11648/j.ajcem.20140206.11},
  url = {https://doi.org/10.11648/j.ajcem.20140206.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20140206.11},
  abstract = {Purpose of this study was to determine the variant of CARD 15 gene mutations with periodontitis chronic .Identified by using polymerase chain reaction (PCR) and folowed by using restriction fragment length polymorphism analysis (RFLP). CARD 15 gene mutation with chronic periodontitis were found heterozygote mutation and homozygote mutation variants base on statistical analysis there were significant with control group ( p= 0,005) and also was founded genetics variation that changed the composition of C → T nucleotide at codon 802 in exon 4 amino acid, from alanine to valine.},
 year = {2014}
}

Copy | Download

TY  - JOUR
T1  - The Analysis Mutation of the CARD15 Gene Variants in Chronic Periodontitis
AU  - Asmawati Amin
AU  - Bahruddin Thalib
AU  - Mochammad Hatta
Y1  - 2014/10/30
PY  - 2014
N1  - https://doi.org/10.11648/j.ajcem.20140206.11
DO  - 10.11648/j.ajcem.20140206.11
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 117
EP  - 122
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20140206.11
AB  - Purpose of this study was to determine the variant of CARD 15 gene mutations with periodontitis chronic .Identified by using polymerase chain reaction (PCR) and folowed by using restriction fragment length polymorphism analysis (RFLP). CARD 15 gene mutation with chronic periodontitis were found heterozygote mutation and homozygote mutation variants base on statistical analysis there were significant with control group ( p= 0,005) and also was founded genetics variation that changed the composition of C → T nucleotide at codon 802 in exon 4 amino acid, from alanine to valine.
VL  - 2
IS  - 6
ER  -

Copy | Download

Author Information

Asmawati Amin

Department of Oral Biology, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia
Bahruddin Thalib

Department, of Prosthodontia, Faculty of Dentistry , Hasanuddin University, Makassar, Indonesia
Mochammad Hatta

Molecular Biology and Immunology Laboratory for Infectious Diseases, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Asmawati Amin, Bahruddin Thalib, Mochammad Hatta. (2014). The Analysis Mutation of the CARD15 Gene Variants in Chronic Periodontitis. American Journal of Clinical and Experimental Medicine, 2(6), 117-122. https://doi.org/10.11648/j.ajcem.20140206.11

Copy | Download

ACS Style

Asmawati Amin; Bahruddin Thalib; Mochammad Hatta. The Analysis Mutation of the CARD15 Gene Variants in Chronic Periodontitis. Am. J. Clin. Exp. Med. 2014, 2(6), 117-122. doi: 10.11648/j.ajcem.20140206.11

Copy | Download

AMA Style

Asmawati Amin, Bahruddin Thalib, Mochammad Hatta. The Analysis Mutation of the CARD15 Gene Variants in Chronic Periodontitis. Am J Clin Exp Med. 2014;2(6):117-122. doi: 10.11648/j.ajcem.20140206.11

Copy | Download

@article{10.11648/j.ajcem.20140206.11,
  author = {Asmawati Amin and Bahruddin Thalib and Mochammad Hatta},
  title = {The Analysis Mutation of the CARD15 Gene Variants in Chronic Periodontitis},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {2},
  number = {6},
  pages = {117-122},
  doi = {10.11648/j.ajcem.20140206.11},
  url = {https://doi.org/10.11648/j.ajcem.20140206.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20140206.11},
  abstract = {Purpose of this study was to determine the variant of CARD 15 gene mutations with periodontitis chronic .Identified by using polymerase chain reaction (PCR) and folowed by using restriction fragment length polymorphism analysis (RFLP). CARD 15 gene mutation with chronic periodontitis were found heterozygote mutation and homozygote mutation variants base on statistical analysis there were significant with control group ( p= 0,005) and also was founded genetics variation that changed the composition of C → T nucleotide at codon 802 in exon 4 amino acid, from alanine to valine.},
 year = {2014}
}

Copy | Download

TY  - JOUR
T1  - The Analysis Mutation of the CARD15 Gene Variants in Chronic Periodontitis
AU  - Asmawati Amin
AU  - Bahruddin Thalib
AU  - Mochammad Hatta
Y1  - 2014/10/30
PY  - 2014
N1  - https://doi.org/10.11648/j.ajcem.20140206.11
DO  - 10.11648/j.ajcem.20140206.11
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 117
EP  - 122
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20140206.11
AB  - Purpose of this study was to determine the variant of CARD 15 gene mutations with periodontitis chronic .Identified by using polymerase chain reaction (PCR) and folowed by using restriction fragment length polymorphism analysis (RFLP). CARD 15 gene mutation with chronic periodontitis were found heterozygote mutation and homozygote mutation variants base on statistical analysis there were significant with control group ( p= 0,005) and also was founded genetics variation that changed the composition of C → T nucleotide at codon 802 in exon 4 amino acid, from alanine to valine.
VL  - 2
IS  - 6
ER  -

Copy | Download