The Significance of Fas/Fasl Expression in Celiac Disease, Non-Specific Duedonitis and in Duedonum Biopsies Showing Increase in Intraepithelial Lymphocytes

Nurdan Tatar; Serdar Yanık; Ayse Neslin Akkoca; Zeynep Tugba Ozdemir; Mustafa Calıskan; Didem Sozutek; Pınar Atasoy

doi:doi:10.11648/j.ajcem.20140205.14

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The Significance of Fas/Fasl Expression in Celiac Disease, Non-Specific Duedonitis and in Duedonum Biopsies Showing Increase in Intraepithelial Lymphocytes

Nurdan Tatar, Serdar Yanık, Ayse Neslin Akkoca, Zeynep Tugba Ozdemir, Mustafa Calıskan, Didem Sozutek, Pınar Atasoy

Published in American Journal of Clinical and Experimental Medicine (Volume 2, Issue 5)

Received: 26 September 2014 Accepted: 9 October 2014 Published: 20 October 2014

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Abstract

Aim: Celiac disease (CD) is a chronic malabsorbtion disease of the small bowel. With a prevelance of about %1 it is a common disease in the community. FAS-FASL system which induces apopitosis is one of the most important pathways and responsible fort he development of mucosal atrophy in CD. The aim of this study is to investigate the patients who has the increase of intraepithelial lymphocytes (İEL) in duedonal mucosa and non specific duedonitis (NSD) and significance of FAS-FASL expression in these patients to distinct from CD.Materials and methods: 29 adults and 7 children celiac patients (with a preliminary diagnosis as iron deficiency anemia) and 17 adults and 6 children non-specific duedonitis patients included in the study. CD3, CD8, FAS and FASL expression were examined immunohistochemically from sections prepared from paraffin blocks in 28 adults and 7 children with normal duedonal mucosa and 24 adults and 6 children who has the increase of İEL in duedonum.Results: İn all groups; the number of İEL seen much more with CD3 in HE (hematoxylin eosin) sections . Again in all groups it is determined that majority of İEL expresses CD3 and CD8. Both in adult and children group; in surface and crypt enterosits in İEL ; the highest FAS expression was seen in enterosits and lamina propria cells in CD .More expression was determined in patients with the group who has İEL in duedonum and with NSD when compared to control group. FASL expression is increased in CD in comparison with normal but it was low in the group who has İEL in duedonum and NSD group. We found that FAS-FASL expression is not only an effective mechanism in pathogenesis of CD. We suggest that the functional significance of FAS expression should be investigated by methods of evaluating apopitosis in patients with İELAG and NSD who has more FAS expression when compared to CD . Also in the detection of number of İEL in suspected cases routine use of CD3 immunohistochemical evaluation may be useful.

Published in	American Journal of Clinical and Experimental Medicine (Volume 2, Issue 5)
DOI	10.11648/j.ajcem.20140205.14
Page(s)	106-116
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Celiac Disease (CD), İncreased İntraepithelial Lymphocytes (İEL),Non-Spesific Duedonitis(NSD), FAS, FASL

References

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Nurdan Tatar, Serdar Yanık, Ayse Neslin Akkoca, Zeynep Tugba Ozdemir, Mustafa Calıskan, et al. (2014). The Significance of Fas/Fasl Expression in Celiac Disease, Non-Specific Duedonitis and in Duedonum Biopsies Showing Increase in Intraepithelial Lymphocytes. American Journal of Clinical and Experimental Medicine, 2(5), 106-116. https://doi.org/10.11648/j.ajcem.20140205.14

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Nurdan Tatar; Serdar Yanık; Ayse Neslin Akkoca; Zeynep Tugba Ozdemir; Mustafa Calıskan, et al. The Significance of Fas/Fasl Expression in Celiac Disease, Non-Specific Duedonitis and in Duedonum Biopsies Showing Increase in Intraepithelial Lymphocytes. Am. J. Clin. Exp. Med. 2014, 2(5), 106-116. doi: 10.11648/j.ajcem.20140205.14

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Nurdan Tatar, Serdar Yanık, Ayse Neslin Akkoca, Zeynep Tugba Ozdemir, Mustafa Calıskan, et al. The Significance of Fas/Fasl Expression in Celiac Disease, Non-Specific Duedonitis and in Duedonum Biopsies Showing Increase in Intraepithelial Lymphocytes. Am J Clin Exp Med. 2014;2(5):106-116. doi: 10.11648/j.ajcem.20140205.14

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@article{10.11648/j.ajcem.20140205.14,
  author = {Nurdan Tatar and Serdar Yanık and Ayse Neslin Akkoca and Zeynep Tugba Ozdemir and Mustafa Calıskan and Didem Sozutek and Pınar Atasoy},
  title = {The Significance of Fas/Fasl Expression in Celiac Disease, Non-Specific Duedonitis and in Duedonum Biopsies Showing Increase in Intraepithelial Lymphocytes},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {2},
  number = {5},
  pages = {106-116},
  doi = {10.11648/j.ajcem.20140205.14},
  url = {https://doi.org/10.11648/j.ajcem.20140205.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20140205.14},
  abstract = {Aim: Celiac disease (CD) is a chronic malabsorbtion disease of the small bowel. With a prevelance of about %1 it is a common disease in the community. FAS-FASL system which induces apopitosis is one of the most important pathways and responsible fort he development of mucosal atrophy in CD. The aim of this study is to investigate the patients who has the increase of intraepithelial lymphocytes (İEL) in duedonal mucosa and non specific duedonitis (NSD) and significance of FAS-FASL expression in these patients to distinct from CD.Materials and methods: 29 adults and 7 children celiac patients (with a preliminary diagnosis as iron deficiency anemia) and 17 adults and 6 children non-specific duedonitis patients included in the study. CD3, CD8, FAS and FASL expression were examined immunohistochemically from sections prepared from paraffin blocks in 28 adults and 7 children with normal duedonal mucosa and 24 adults and 6 children who has the increase of İEL in duedonum.Results: İn all groups; the number of İEL seen much more with CD3 in HE (hematoxylin eosin) sections . Again in all groups it is determined that majority of İEL expresses CD3 and CD8. Both in adult and children group; in surface and crypt enterosits in İEL ; the highest FAS expression was seen in enterosits and lamina propria cells in CD .More expression was determined in patients with the group who has İEL in duedonum and with NSD when compared to control group. FASL expression is increased in CD in comparison with normal but it was low in the group who has İEL in duedonum and NSD group. We found that FAS-FASL expression is not only an effective mechanism in pathogenesis of CD. We suggest that the functional significance of FAS expression should be investigated by methods of evaluating apopitosis in patients with İELAG and NSD who has more FAS expression when compared to CD . Also in the detection of number of İEL in suspected cases routine use of CD3 immunohistochemical evaluation may be useful.},
 year = {2014}
}

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TY  - JOUR
T1  - The Significance of Fas/Fasl Expression in Celiac Disease, Non-Specific Duedonitis and in Duedonum Biopsies Showing Increase in Intraepithelial Lymphocytes
AU  - Nurdan Tatar
AU  - Serdar Yanık
AU  - Ayse Neslin Akkoca
AU  - Zeynep Tugba Ozdemir
AU  - Mustafa Calıskan
AU  - Didem Sozutek
AU  - Pınar Atasoy
Y1  - 2014/10/20
PY  - 2014
N1  - https://doi.org/10.11648/j.ajcem.20140205.14
DO  - 10.11648/j.ajcem.20140205.14
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 106
EP  - 116
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20140205.14
AB  - Aim: Celiac disease (CD) is a chronic malabsorbtion disease of the small bowel. With a prevelance of about %1 it is a common disease in the community. FAS-FASL system which induces apopitosis is one of the most important pathways and responsible fort he development of mucosal atrophy in CD. The aim of this study is to investigate the patients who has the increase of intraepithelial lymphocytes (İEL) in duedonal mucosa and non specific duedonitis (NSD) and significance of FAS-FASL expression in these patients to distinct from CD.Materials and methods: 29 adults and 7 children celiac patients (with a preliminary diagnosis as iron deficiency anemia) and 17 adults and 6 children non-specific duedonitis patients included in the study. CD3, CD8, FAS and FASL expression were examined immunohistochemically from sections prepared from paraffin blocks in 28 adults and 7 children with normal duedonal mucosa and 24 adults and 6 children who has the increase of İEL in duedonum.Results: İn all groups; the number of İEL seen much more with CD3 in HE (hematoxylin eosin) sections . Again in all groups it is determined that majority of İEL expresses CD3 and CD8. Both in adult and children group; in surface and crypt enterosits in İEL ; the highest FAS expression was seen in enterosits and lamina propria cells in CD .More expression was determined in patients with the group who has İEL in duedonum and with NSD when compared to control group. FASL expression is increased in CD in comparison with normal but it was low in the group who has İEL in duedonum and NSD group. We found that FAS-FASL expression is not only an effective mechanism in pathogenesis of CD. We suggest that the functional significance of FAS expression should be investigated by methods of evaluating apopitosis in patients with İELAG and NSD who has more FAS expression when compared to CD . Also in the detection of number of İEL in suspected cases routine use of CD3 immunohistochemical evaluation may be useful.
VL  - 2
IS  - 5
ER  -

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Nurdan Tatar

Iskenderun State Hospital, Department of Pathology, Hatay, Turkey
Serdar Yanık
Ayse Neslin Akkoca

Iskenderun State Hospital ,Department of Family Medicine, Hatay, Turkey
Zeynep Tugba Ozdemir

Bozok University Faculty of Medicine, Department of Internal Medicine, Yozgat, Turkey
Mustafa Calıskan
Didem Sozutek

Iskenderun State Hospital, Department of Internal Medicine, Hatay, Turkey
Pınar Atasoy

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Nurdan Tatar, Serdar Yanık, Ayse Neslin Akkoca, Zeynep Tugba Ozdemir, Mustafa Calıskan, et al. (2014). The Significance of Fas/Fasl Expression in Celiac Disease, Non-Specific Duedonitis and in Duedonum Biopsies Showing Increase in Intraepithelial Lymphocytes. American Journal of Clinical and Experimental Medicine, 2(5), 106-116. https://doi.org/10.11648/j.ajcem.20140205.14

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Nurdan Tatar; Serdar Yanık; Ayse Neslin Akkoca; Zeynep Tugba Ozdemir; Mustafa Calıskan, et al. The Significance of Fas/Fasl Expression in Celiac Disease, Non-Specific Duedonitis and in Duedonum Biopsies Showing Increase in Intraepithelial Lymphocytes. Am. J. Clin. Exp. Med. 2014, 2(5), 106-116. doi: 10.11648/j.ajcem.20140205.14

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AMA Style

Nurdan Tatar, Serdar Yanık, Ayse Neslin Akkoca, Zeynep Tugba Ozdemir, Mustafa Calıskan, et al. The Significance of Fas/Fasl Expression in Celiac Disease, Non-Specific Duedonitis and in Duedonum Biopsies Showing Increase in Intraepithelial Lymphocytes. Am J Clin Exp Med. 2014;2(5):106-116. doi: 10.11648/j.ajcem.20140205.14

Copy | Download

@article{10.11648/j.ajcem.20140205.14,
  author = {Nurdan Tatar and Serdar Yanık and Ayse Neslin Akkoca and Zeynep Tugba Ozdemir and Mustafa Calıskan and Didem Sozutek and Pınar Atasoy},
  title = {The Significance of Fas/Fasl Expression in Celiac Disease, Non-Specific Duedonitis and in Duedonum Biopsies Showing Increase in Intraepithelial Lymphocytes},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {2},
  number = {5},
  pages = {106-116},
  doi = {10.11648/j.ajcem.20140205.14},
  url = {https://doi.org/10.11648/j.ajcem.20140205.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20140205.14},
  abstract = {Aim: Celiac disease (CD) is a chronic malabsorbtion disease of the small bowel. With a prevelance of about %1 it is a common disease in the community. FAS-FASL system which induces apopitosis is one of the most important pathways and responsible fort he development of mucosal atrophy in CD. The aim of this study is to investigate the patients who has the increase of intraepithelial lymphocytes (İEL) in duedonal mucosa and non specific duedonitis (NSD) and significance of FAS-FASL expression in these patients to distinct from CD.Materials and methods: 29 adults and 7 children celiac patients (with a preliminary diagnosis as iron deficiency anemia) and 17 adults and 6 children non-specific duedonitis patients included in the study. CD3, CD8, FAS and FASL expression were examined immunohistochemically from sections prepared from paraffin blocks in 28 adults and 7 children with normal duedonal mucosa and 24 adults and 6 children who has the increase of İEL in duedonum.Results: İn all groups; the number of İEL seen much more with CD3 in HE (hematoxylin eosin) sections . Again in all groups it is determined that majority of İEL expresses CD3 and CD8. Both in adult and children group; in surface and crypt enterosits in İEL ; the highest FAS expression was seen in enterosits and lamina propria cells in CD .More expression was determined in patients with the group who has İEL in duedonum and with NSD when compared to control group. FASL expression is increased in CD in comparison with normal but it was low in the group who has İEL in duedonum and NSD group. We found that FAS-FASL expression is not only an effective mechanism in pathogenesis of CD. We suggest that the functional significance of FAS expression should be investigated by methods of evaluating apopitosis in patients with İELAG and NSD who has more FAS expression when compared to CD . Also in the detection of number of İEL in suspected cases routine use of CD3 immunohistochemical evaluation may be useful.},
 year = {2014}
}

Copy | Download

TY  - JOUR
T1  - The Significance of Fas/Fasl Expression in Celiac Disease, Non-Specific Duedonitis and in Duedonum Biopsies Showing Increase in Intraepithelial Lymphocytes
AU  - Nurdan Tatar
AU  - Serdar Yanık
AU  - Ayse Neslin Akkoca
AU  - Zeynep Tugba Ozdemir
AU  - Mustafa Calıskan
AU  - Didem Sozutek
AU  - Pınar Atasoy
Y1  - 2014/10/20
PY  - 2014
N1  - https://doi.org/10.11648/j.ajcem.20140205.14
DO  - 10.11648/j.ajcem.20140205.14
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 106
EP  - 116
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20140205.14
AB  - Aim: Celiac disease (CD) is a chronic malabsorbtion disease of the small bowel. With a prevelance of about %1 it is a common disease in the community. FAS-FASL system which induces apopitosis is one of the most important pathways and responsible fort he development of mucosal atrophy in CD. The aim of this study is to investigate the patients who has the increase of intraepithelial lymphocytes (İEL) in duedonal mucosa and non specific duedonitis (NSD) and significance of FAS-FASL expression in these patients to distinct from CD.Materials and methods: 29 adults and 7 children celiac patients (with a preliminary diagnosis as iron deficiency anemia) and 17 adults and 6 children non-specific duedonitis patients included in the study. CD3, CD8, FAS and FASL expression were examined immunohistochemically from sections prepared from paraffin blocks in 28 adults and 7 children with normal duedonal mucosa and 24 adults and 6 children who has the increase of İEL in duedonum.Results: İn all groups; the number of İEL seen much more with CD3 in HE (hematoxylin eosin) sections . Again in all groups it is determined that majority of İEL expresses CD3 and CD8. Both in adult and children group; in surface and crypt enterosits in İEL ; the highest FAS expression was seen in enterosits and lamina propria cells in CD .More expression was determined in patients with the group who has İEL in duedonum and with NSD when compared to control group. FASL expression is increased in CD in comparison with normal but it was low in the group who has İEL in duedonum and NSD group. We found that FAS-FASL expression is not only an effective mechanism in pathogenesis of CD. We suggest that the functional significance of FAS expression should be investigated by methods of evaluating apopitosis in patients with İELAG and NSD who has more FAS expression when compared to CD . Also in the detection of number of İEL in suspected cases routine use of CD3 immunohistochemical evaluation may be useful.
VL  - 2
IS  - 5
ER  -

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