Synthesis, Characterization, 3D Modeling, Biological Activities of Some Metal Complexes of Novel Sulpha Drug Schiff Base Ligand and Its Nano Cu Complex

Tarek M. Ismail; Mosad A. EL Ghamry; Samy M. Abu-El-Wafa; Doaa F. Sallam

doi:doi:10.11648/j.mc.20150302.12

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Synthesis, Characterization, 3D Modeling, Biological Activities of Some Metal Complexes of Novel Sulpha Drug Schiff Base Ligand and Its Nano Cu Complex

Tarek M. Ismail, Mosad A. EL Ghamry, Samy M. Abu-El-Wafa, Doaa F. Sallam

Published in Modern Chemistry (Volume 3, Issue 2)

Received: 1 April 2015 Accepted: 7 April 2015 Published: 27 April 2015

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Abstract

Novel solid Co(II), Ni(II), Cu(II) and Zn(II) complexes of sulpha drug Schiff base ligand (HL) derived from condensation of sulphaquinoxaline and naphthaldehyde namely, 2-{4-[(2-hydroxynaphthalen-1-yl) methyleneamino] benzenesulfonamido} quinoxalin (HNMABSQ), in addition new mixed ligand complexes with 8-hydroxyquinoline (8-HQ) or 1,10 Phenanthroline (1,10 Phen) with HL and these metal (II) ions were synthesized. The structure of complexes were proposed in light of analytical, IR, 1H-NMR, Mass, UV-Vis, ESR spectral data, magnetic and thermal studies. The molar conductance data reveal that all the metal chelates were non-electrolytes. The kinetic and thermodynamic parameters for decomposition steps in Co(II), Ni(II) and Cu(II) complexes thermo grams were calculated. On the basis of these studies, most complexes have octahedral geometry but few can attain the square planar arrangement. 3D modeling of the ligand and its metal complexes were studied by PM3 method, also the heat of formations, HOMO, LUMO and dipole moments were calculated to confirm the geometry of the ligand and its complexes. Schiff base ligand and its metal complexes were tested for antimicrobial activities. Nano-Cu- Schiff base complex was synthesized and characterized by scanning electron microscopy (SEM) and its biological activities were studied. The Cu nano complex had higher antibacterial and antifungal activity than the ligand and its metal complexes. Also, all tested compounds inhibited the growth of the liver cancer cell.

Published in	Modern Chemistry (Volume 3, Issue 2)
DOI	10.11648/j.mc.20150302.12
Page(s)	18-30
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Sulphaquinoxaline, Schiff Base, Metal Complexes, Spectral Studies, Antimicrobial, Anticancer Activity, Nano Complexes

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APA Style

Tarek M. Ismail, Mosad A. EL Ghamry, Samy M. Abu-El-Wafa, Doaa F. Sallam. (2015). Synthesis, Characterization, 3D Modeling, Biological Activities of Some Metal Complexes of Novel Sulpha Drug Schiff Base Ligand and Its Nano Cu Complex. Modern Chemistry, 3(2), 18-30. https://doi.org/10.11648/j.mc.20150302.12

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ACS Style

Tarek M. Ismail; Mosad A. EL Ghamry; Samy M. Abu-El-Wafa; Doaa F. Sallam. Synthesis, Characterization, 3D Modeling, Biological Activities of Some Metal Complexes of Novel Sulpha Drug Schiff Base Ligand and Its Nano Cu Complex. Mod. Chem. 2015, 3(2), 18-30. doi: 10.11648/j.mc.20150302.12

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AMA Style

Tarek M. Ismail, Mosad A. EL Ghamry, Samy M. Abu-El-Wafa, Doaa F. Sallam. Synthesis, Characterization, 3D Modeling, Biological Activities of Some Metal Complexes of Novel Sulpha Drug Schiff Base Ligand and Its Nano Cu Complex. Mod Chem. 2015;3(2):18-30. doi: 10.11648/j.mc.20150302.12

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@article{10.11648/j.mc.20150302.12,
  author = {Tarek M. Ismail and Mosad A. EL Ghamry and Samy M. Abu-El-Wafa and Doaa F. Sallam},
  title = {Synthesis, Characterization, 3D Modeling, Biological Activities of Some Metal Complexes of Novel Sulpha Drug Schiff Base Ligand and Its Nano Cu Complex},
  journal = {Modern Chemistry},
  volume = {3},
  number = {2},
  pages = {18-30},
  doi = {10.11648/j.mc.20150302.12},
  url = {https://doi.org/10.11648/j.mc.20150302.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.mc.20150302.12},
  abstract = {Novel solid Co(II), Ni(II), Cu(II) and Zn(II) complexes of sulpha drug Schiff base ligand (HL) derived from condensation of sulphaquinoxaline and naphthaldehyde namely, 2-{4-[(2-hydroxynaphthalen-1-yl) methyleneamino] benzenesulfonamido} quinoxalin (HNMABSQ), in addition new mixed ligand complexes with 8-hydroxyquinoline (8-HQ) or 1,10 Phenanthroline (1,10 Phen) with HL and these metal (II) ions were synthesized. The structure of complexes were proposed in light of analytical, IR, 1H-NMR, Mass, UV-Vis, ESR spectral data, magnetic and thermal studies. The molar conductance data reveal that all the metal chelates were non-electrolytes. The kinetic and thermodynamic parameters for decomposition steps in Co(II), Ni(II) and Cu(II) complexes thermo grams were calculated. On the basis of these studies, most complexes have octahedral geometry but few can attain the square planar arrangement. 3D modeling of the ligand and its metal complexes were studied by PM3 method, also the heat of formations, HOMO, LUMO and dipole moments were calculated to confirm the geometry of the ligand and its complexes. Schiff base ligand and its metal complexes were tested for antimicrobial activities. Nano-Cu- Schiff base complex was synthesized and characterized by scanning electron microscopy (SEM) and its biological activities were studied. The Cu nano complex had higher antibacterial and antifungal activity than the ligand and its metal complexes. Also, all tested compounds inhibited the growth of the liver cancer cell.},
 year = {2015}
}

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TY  - JOUR
T1  - Synthesis, Characterization, 3D Modeling, Biological Activities of Some Metal Complexes of Novel Sulpha Drug Schiff Base Ligand and Its Nano Cu Complex
AU  - Tarek M. Ismail
AU  - Mosad A. EL Ghamry
AU  - Samy M. Abu-El-Wafa
AU  - Doaa F. Sallam
Y1  - 2015/04/27
PY  - 2015
N1  - https://doi.org/10.11648/j.mc.20150302.12
DO  - 10.11648/j.mc.20150302.12
T2  - Modern Chemistry
JF  - Modern Chemistry
JO  - Modern Chemistry
SP  - 18
EP  - 30
PB  - Science Publishing Group
SN  - 2329-180X
UR  - https://doi.org/10.11648/j.mc.20150302.12
AB  - Novel solid Co(II), Ni(II), Cu(II) and Zn(II) complexes of sulpha drug Schiff base ligand (HL) derived from condensation of sulphaquinoxaline and naphthaldehyde namely, 2-{4-[(2-hydroxynaphthalen-1-yl) methyleneamino] benzenesulfonamido} quinoxalin (HNMABSQ), in addition new mixed ligand complexes with 8-hydroxyquinoline (8-HQ) or 1,10 Phenanthroline (1,10 Phen) with HL and these metal (II) ions were synthesized. The structure of complexes were proposed in light of analytical, IR, 1H-NMR, Mass, UV-Vis, ESR spectral data, magnetic and thermal studies. The molar conductance data reveal that all the metal chelates were non-electrolytes. The kinetic and thermodynamic parameters for decomposition steps in Co(II), Ni(II) and Cu(II) complexes thermo grams were calculated. On the basis of these studies, most complexes have octahedral geometry but few can attain the square planar arrangement. 3D modeling of the ligand and its metal complexes were studied by PM3 method, also the heat of formations, HOMO, LUMO and dipole moments were calculated to confirm the geometry of the ligand and its complexes. Schiff base ligand and its metal complexes were tested for antimicrobial activities. Nano-Cu- Schiff base complex was synthesized and characterized by scanning electron microscopy (SEM) and its biological activities were studied. The Cu nano complex had higher antibacterial and antifungal activity than the ligand and its metal complexes. Also, all tested compounds inhibited the growth of the liver cancer cell.
VL  - 3
IS  - 2
ER  -

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Author Information

Tarek M. Ismail

Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo, Egypt
Mosad A. EL Ghamry

Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo, Egypt
Samy M. Abu-El-Wafa

Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo, Egypt
Doaa F. Sallam

Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo, Egypt

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Tarek M. Ismail, Mosad A. EL Ghamry, Samy M. Abu-El-Wafa, Doaa F. Sallam. (2015). Synthesis, Characterization, 3D Modeling, Biological Activities of Some Metal Complexes of Novel Sulpha Drug Schiff Base Ligand and Its Nano Cu Complex. Modern Chemistry, 3(2), 18-30. https://doi.org/10.11648/j.mc.20150302.12

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ACS Style

Tarek M. Ismail; Mosad A. EL Ghamry; Samy M. Abu-El-Wafa; Doaa F. Sallam. Synthesis, Characterization, 3D Modeling, Biological Activities of Some Metal Complexes of Novel Sulpha Drug Schiff Base Ligand and Its Nano Cu Complex. Mod. Chem. 2015, 3(2), 18-30. doi: 10.11648/j.mc.20150302.12

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AMA Style

Tarek M. Ismail, Mosad A. EL Ghamry, Samy M. Abu-El-Wafa, Doaa F. Sallam. Synthesis, Characterization, 3D Modeling, Biological Activities of Some Metal Complexes of Novel Sulpha Drug Schiff Base Ligand and Its Nano Cu Complex. Mod Chem. 2015;3(2):18-30. doi: 10.11648/j.mc.20150302.12

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@article{10.11648/j.mc.20150302.12,
  author = {Tarek M. Ismail and Mosad A. EL Ghamry and Samy M. Abu-El-Wafa and Doaa F. Sallam},
  title = {Synthesis, Characterization, 3D Modeling, Biological Activities of Some Metal Complexes of Novel Sulpha Drug Schiff Base Ligand and Its Nano Cu Complex},
  journal = {Modern Chemistry},
  volume = {3},
  number = {2},
  pages = {18-30},
  doi = {10.11648/j.mc.20150302.12},
  url = {https://doi.org/10.11648/j.mc.20150302.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.mc.20150302.12},
  abstract = {Novel solid Co(II), Ni(II), Cu(II) and Zn(II) complexes of sulpha drug Schiff base ligand (HL) derived from condensation of sulphaquinoxaline and naphthaldehyde namely, 2-{4-[(2-hydroxynaphthalen-1-yl) methyleneamino] benzenesulfonamido} quinoxalin (HNMABSQ), in addition new mixed ligand complexes with 8-hydroxyquinoline (8-HQ) or 1,10 Phenanthroline (1,10 Phen) with HL and these metal (II) ions were synthesized. The structure of complexes were proposed in light of analytical, IR, 1H-NMR, Mass, UV-Vis, ESR spectral data, magnetic and thermal studies. The molar conductance data reveal that all the metal chelates were non-electrolytes. The kinetic and thermodynamic parameters for decomposition steps in Co(II), Ni(II) and Cu(II) complexes thermo grams were calculated. On the basis of these studies, most complexes have octahedral geometry but few can attain the square planar arrangement. 3D modeling of the ligand and its metal complexes were studied by PM3 method, also the heat of formations, HOMO, LUMO and dipole moments were calculated to confirm the geometry of the ligand and its complexes. Schiff base ligand and its metal complexes were tested for antimicrobial activities. Nano-Cu- Schiff base complex was synthesized and characterized by scanning electron microscopy (SEM) and its biological activities were studied. The Cu nano complex had higher antibacterial and antifungal activity than the ligand and its metal complexes. Also, all tested compounds inhibited the growth of the liver cancer cell.},
 year = {2015}
}

Copy | Download

TY  - JOUR
T1  - Synthesis, Characterization, 3D Modeling, Biological Activities of Some Metal Complexes of Novel Sulpha Drug Schiff Base Ligand and Its Nano Cu Complex
AU  - Tarek M. Ismail
AU  - Mosad A. EL Ghamry
AU  - Samy M. Abu-El-Wafa
AU  - Doaa F. Sallam
Y1  - 2015/04/27
PY  - 2015
N1  - https://doi.org/10.11648/j.mc.20150302.12
DO  - 10.11648/j.mc.20150302.12
T2  - Modern Chemistry
JF  - Modern Chemistry
JO  - Modern Chemistry
SP  - 18
EP  - 30
PB  - Science Publishing Group
SN  - 2329-180X
UR  - https://doi.org/10.11648/j.mc.20150302.12
AB  - Novel solid Co(II), Ni(II), Cu(II) and Zn(II) complexes of sulpha drug Schiff base ligand (HL) derived from condensation of sulphaquinoxaline and naphthaldehyde namely, 2-{4-[(2-hydroxynaphthalen-1-yl) methyleneamino] benzenesulfonamido} quinoxalin (HNMABSQ), in addition new mixed ligand complexes with 8-hydroxyquinoline (8-HQ) or 1,10 Phenanthroline (1,10 Phen) with HL and these metal (II) ions were synthesized. The structure of complexes were proposed in light of analytical, IR, 1H-NMR, Mass, UV-Vis, ESR spectral data, magnetic and thermal studies. The molar conductance data reveal that all the metal chelates were non-electrolytes. The kinetic and thermodynamic parameters for decomposition steps in Co(II), Ni(II) and Cu(II) complexes thermo grams were calculated. On the basis of these studies, most complexes have octahedral geometry but few can attain the square planar arrangement. 3D modeling of the ligand and its metal complexes were studied by PM3 method, also the heat of formations, HOMO, LUMO and dipole moments were calculated to confirm the geometry of the ligand and its complexes. Schiff base ligand and its metal complexes were tested for antimicrobial activities. Nano-Cu- Schiff base complex was synthesized and characterized by scanning electron microscopy (SEM) and its biological activities were studied. The Cu nano complex had higher antibacterial and antifungal activity than the ligand and its metal complexes. Also, all tested compounds inhibited the growth of the liver cancer cell.
VL  - 3
IS  - 2
ER  -

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