Ginger is widely used as a spice and also an effective herbal medicine to treat gastrointestinal disorders. On the other hand, stress can induce various modulation of digestive motility. Here, we investigated ginger effects on stress-induced motility of the isolated ileum in male and female rats, in vitro. Rats (Wistar, SPF, 7-12 weeks of age, 148-393 g BW) were divided into Control (1G) and 3G groups. 3G stress (every day for 10 min) was loaded by centrifugal apparatus for 1, 3, 15 and 30 days. After the stress loading at each day, a 1 cm-long section of the ileum was isolated under barbiturate anesthesia and fixed to a Magnus-type chamber filled with Tyrode solution. Ileal movements were observed for 60 s following application of zingerone, which is also called vanillylacetone and a key component of the pungency of ginger (0.1-10 μM). Spontaneous motility movements with phasic and tonic patterns were observed in the ileum. The former was a peristalsis-like movement and the latter was a slow fluctuation of the baseline. Ginger induced enhanced effects on the rhythmic phasic motility in relation to amplitude. In the female, 3G gravity loading had no effects on the ginger-induced motility, however, suppressive effect of the ginger-induced phasic movements was clearly observed at day 15 in the male. The present study showed that gravity stress changed ginger-induced effects on phasic ileal motility in the male, but not in the female, indicating that sex differences were observed in the ginger effects modulated by stress loading.
| Published in |
Journal of Food and Nutrition Sciences (Volume 3, Issue 3-1)
This article belongs to the Special Issue Effects of Foods on Gastrointestinal, Metabolic and Immunological Function |
| DOI | 10.11648/j.jfns.s.2015030301.12 |
| Page(s) | 5-8 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2015. Published by Science Publishing Group |
Ginger, Zingerone, Ileum, Motility, Sex Difference, Rat
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APA Style
Mari Kimoto, Jorge L. Zeredo, Masato S. Ota, Zenro Nihei, Kazuo Toda. (2015). Ginger-induced Ileal Motility is Modified by Stress: Sex Differences in Rats. Journal of Food and Nutrition Sciences, 3(3-1), 5-8. https://doi.org/10.11648/j.jfns.s.2015030301.12
ACS Style
Mari Kimoto; Jorge L. Zeredo; Masato S. Ota; Zenro Nihei; Kazuo Toda. Ginger-induced Ileal Motility is Modified by Stress: Sex Differences in Rats. J. Food Nutr. Sci. 2015, 3(3-1), 5-8. doi: 10.11648/j.jfns.s.2015030301.12
AMA Style
Mari Kimoto, Jorge L. Zeredo, Masato S. Ota, Zenro Nihei, Kazuo Toda. Ginger-induced Ileal Motility is Modified by Stress: Sex Differences in Rats. J Food Nutr Sci. 2015;3(3-1):5-8. doi: 10.11648/j.jfns.s.2015030301.12
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Download@article{10.11648/j.jfns.s.2015030301.12,
author = {Mari Kimoto and Jorge L. Zeredo and Masato S. Ota and Zenro Nihei and Kazuo Toda},
title = {Ginger-induced Ileal Motility is Modified by Stress: Sex Differences in Rats},
journal = {Journal of Food and Nutrition Sciences},
volume = {3},
number = {3-1},
pages = {5-8},
doi = {10.11648/j.jfns.s.2015030301.12},
url = {https://doi.org/10.11648/j.jfns.s.2015030301.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfns.s.2015030301.12},
abstract = {Ginger is widely used as a spice and also an effective herbal medicine to treat gastrointestinal disorders. On the other hand, stress can induce various modulation of digestive motility. Here, we investigated ginger effects on stress-induced motility of the isolated ileum in male and female rats, in vitro. Rats (Wistar, SPF, 7-12 weeks of age, 148-393 g BW) were divided into Control (1G) and 3G groups. 3G stress (every day for 10 min) was loaded by centrifugal apparatus for 1, 3, 15 and 30 days. After the stress loading at each day, a 1 cm-long section of the ileum was isolated under barbiturate anesthesia and fixed to a Magnus-type chamber filled with Tyrode solution. Ileal movements were observed for 60 s following application of zingerone, which is also called vanillylacetone and a key component of the pungency of ginger (0.1-10 μM). Spontaneous motility movements with phasic and tonic patterns were observed in the ileum. The former was a peristalsis-like movement and the latter was a slow fluctuation of the baseline. Ginger induced enhanced effects on the rhythmic phasic motility in relation to amplitude. In the female, 3G gravity loading had no effects on the ginger-induced motility, however, suppressive effect of the ginger-induced phasic movements was clearly observed at day 15 in the male. The present study showed that gravity stress changed ginger-induced effects on phasic ileal motility in the male, but not in the female, indicating that sex differences were observed in the ginger effects modulated by stress loading.},
year = {2015}
}
TY - JOUR T1 - Ginger-induced Ileal Motility is Modified by Stress: Sex Differences in Rats AU - Mari Kimoto AU - Jorge L. Zeredo AU - Masato S. Ota AU - Zenro Nihei AU - Kazuo Toda Y1 - 2015/02/27 PY - 2015 N1 - https://doi.org/10.11648/j.jfns.s.2015030301.12 DO - 10.11648/j.jfns.s.2015030301.12 T2 - Journal of Food and Nutrition Sciences JF - Journal of Food and Nutrition Sciences JO - Journal of Food and Nutrition Sciences SP - 5 EP - 8 PB - Science Publishing Group SN - 2330-7293 UR - https://doi.org/10.11648/j.jfns.s.2015030301.12 AB - Ginger is widely used as a spice and also an effective herbal medicine to treat gastrointestinal disorders. On the other hand, stress can induce various modulation of digestive motility. Here, we investigated ginger effects on stress-induced motility of the isolated ileum in male and female rats, in vitro. Rats (Wistar, SPF, 7-12 weeks of age, 148-393 g BW) were divided into Control (1G) and 3G groups. 3G stress (every day for 10 min) was loaded by centrifugal apparatus for 1, 3, 15 and 30 days. After the stress loading at each day, a 1 cm-long section of the ileum was isolated under barbiturate anesthesia and fixed to a Magnus-type chamber filled with Tyrode solution. Ileal movements were observed for 60 s following application of zingerone, which is also called vanillylacetone and a key component of the pungency of ginger (0.1-10 μM). Spontaneous motility movements with phasic and tonic patterns were observed in the ileum. The former was a peristalsis-like movement and the latter was a slow fluctuation of the baseline. Ginger induced enhanced effects on the rhythmic phasic motility in relation to amplitude. In the female, 3G gravity loading had no effects on the ginger-induced motility, however, suppressive effect of the ginger-induced phasic movements was clearly observed at day 15 in the male. The present study showed that gravity stress changed ginger-induced effects on phasic ileal motility in the male, but not in the female, indicating that sex differences were observed in the ginger effects modulated by stress loading. VL - 3 IS - 3-1 ER -
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