To evaluate the hepatoprotective activity of aqueous extract of Ziziphus jujuba leaves against paracetamol-induced liver injury in experimental rats. Ziziphus jujuba has been traditionally used in the Ayurvedic system of medicine as a chief ingredient in many polyherbal formulations as antioxidant. To evaluate the antioxidant and hepatoprotective activity of aqueous leaf extract of Ziziphus jujuba leaves. Animals were pre-treated with the aqueous leaf extract for 7 days and then toxicity was induced with a single paracetamol oral injection. Pre-treatment with 150mg/kg of aqueous leaf extract of Ziziphus jujuba improved the reduced glutathione (oxidized), SOD, catalase, and peroxidase levels significantly as compared to control group. Silymarin was used as standard reference and exhibited significant hepatoprotective activity against paracetamol induced hepatotoxicity in rats. The biochemical observation was reported for rat liver sections. The results of this study strongly indicate that Ziziphus jujuba leaves have potent hepatoprotective action against paracetamol induced hepatic damage in rats. Aqueous extract was found more potent hepatoprotective. Meanwhile, in vivo antioxidant activities were also screened which were positive for aqueous extracts. On the basis of this study, we conclude that aqueous extract of Ziziphus jujuba possesses in vivo antioxidant activity and can be employed in protecting tissues from oxidative damage and stress.
| Published in |
Journal of Diseases and Medicinal Plants (Volume 2, Issue 1-1)
This article belongs to the Special Issue Pharmacological Action of Medicinal Plants: Health and Diseases |
| DOI | 10.11648/j.jdmp.s.2016020101.11 |
| Page(s) | 1-10 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2016. Published by Science Publishing Group |
Ziziphus jujuba, Silymarin, Paracetamol, Biochemical Markers, Hepatoprotective
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APA Style
J. Preethi, K. Vennila, S. Penislusshiyan, S. Velvizhi. (2016). Hepatoprotective and Antioxidant Role of Ziziphus jujuba Leaves on Paracetamol Induced Hepatic Damage in Rats. Journal of Diseases and Medicinal Plants, 2(1-1), 1-10. https://doi.org/10.11648/j.jdmp.s.2016020101.11
ACS Style
J. Preethi; K. Vennila; S. Penislusshiyan; S. Velvizhi. Hepatoprotective and Antioxidant Role of Ziziphus jujuba Leaves on Paracetamol Induced Hepatic Damage in Rats. J. Dis. Med. Plants 2016, 2(1-1), 1-10. doi: 10.11648/j.jdmp.s.2016020101.11
AMA Style
J. Preethi, K. Vennila, S. Penislusshiyan, S. Velvizhi. Hepatoprotective and Antioxidant Role of Ziziphus jujuba Leaves on Paracetamol Induced Hepatic Damage in Rats. J Dis Med Plants. 2016;2(1-1):1-10. doi: 10.11648/j.jdmp.s.2016020101.11
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Download@article{10.11648/j.jdmp.s.2016020101.11,
author = {J. Preethi and K. Vennila and S. Penislusshiyan and S. Velvizhi},
title = {Hepatoprotective and Antioxidant Role of Ziziphus jujuba Leaves on Paracetamol Induced Hepatic Damage in Rats},
journal = {Journal of Diseases and Medicinal Plants},
volume = {2},
number = {1-1},
pages = {1-10},
doi = {10.11648/j.jdmp.s.2016020101.11},
url = {https://doi.org/10.11648/j.jdmp.s.2016020101.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.s.2016020101.11},
abstract = {To evaluate the hepatoprotective activity of aqueous extract of Ziziphus jujuba leaves against paracetamol-induced liver injury in experimental rats. Ziziphus jujuba has been traditionally used in the Ayurvedic system of medicine as a chief ingredient in many polyherbal formulations as antioxidant. To evaluate the antioxidant and hepatoprotective activity of aqueous leaf extract of Ziziphus jujuba leaves. Animals were pre-treated with the aqueous leaf extract for 7 days and then toxicity was induced with a single paracetamol oral injection. Pre-treatment with 150mg/kg of aqueous leaf extract of Ziziphus jujuba improved the reduced glutathione (oxidized), SOD, catalase, and peroxidase levels significantly as compared to control group. Silymarin was used as standard reference and exhibited significant hepatoprotective activity against paracetamol induced hepatotoxicity in rats. The biochemical observation was reported for rat liver sections. The results of this study strongly indicate that Ziziphus jujuba leaves have potent hepatoprotective action against paracetamol induced hepatic damage in rats. Aqueous extract was found more potent hepatoprotective. Meanwhile, in vivo antioxidant activities were also screened which were positive for aqueous extracts. On the basis of this study, we conclude that aqueous extract of Ziziphus jujuba possesses in vivo antioxidant activity and can be employed in protecting tissues from oxidative damage and stress.},
year = {2016}
}
TY - JOUR T1 - Hepatoprotective and Antioxidant Role of Ziziphus jujuba Leaves on Paracetamol Induced Hepatic Damage in Rats AU - J. Preethi AU - K. Vennila AU - S. Penislusshiyan AU - S. Velvizhi Y1 - 2016/02/23 PY - 2016 N1 - https://doi.org/10.11648/j.jdmp.s.2016020101.11 DO - 10.11648/j.jdmp.s.2016020101.11 T2 - Journal of Diseases and Medicinal Plants JF - Journal of Diseases and Medicinal Plants JO - Journal of Diseases and Medicinal Plants SP - 1 EP - 10 PB - Science Publishing Group SN - 2469-8210 UR - https://doi.org/10.11648/j.jdmp.s.2016020101.11 AB - To evaluate the hepatoprotective activity of aqueous extract of Ziziphus jujuba leaves against paracetamol-induced liver injury in experimental rats. Ziziphus jujuba has been traditionally used in the Ayurvedic system of medicine as a chief ingredient in many polyherbal formulations as antioxidant. To evaluate the antioxidant and hepatoprotective activity of aqueous leaf extract of Ziziphus jujuba leaves. Animals were pre-treated with the aqueous leaf extract for 7 days and then toxicity was induced with a single paracetamol oral injection. Pre-treatment with 150mg/kg of aqueous leaf extract of Ziziphus jujuba improved the reduced glutathione (oxidized), SOD, catalase, and peroxidase levels significantly as compared to control group. Silymarin was used as standard reference and exhibited significant hepatoprotective activity against paracetamol induced hepatotoxicity in rats. The biochemical observation was reported for rat liver sections. The results of this study strongly indicate that Ziziphus jujuba leaves have potent hepatoprotective action against paracetamol induced hepatic damage in rats. Aqueous extract was found more potent hepatoprotective. Meanwhile, in vivo antioxidant activities were also screened which were positive for aqueous extracts. On the basis of this study, we conclude that aqueous extract of Ziziphus jujuba possesses in vivo antioxidant activity and can be employed in protecting tissues from oxidative damage and stress. VL - 2 IS - 1-1 ER -
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