The Impact of the Oxidative Stress and Inflammatory Process on the Serum Levels of Malonaldialdehyde, Glutathione Peroxidase, and Interlukine-18 in Patients with Essential Hypertension

Salar Fatih Kudhur; Shatha Rouf Moustafa

doi:doi:10.11648/j.ajim.20150303.15

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The Impact of the Oxidative Stress and Inflammatory Process on the Serum Levels of Malonaldialdehyde, Glutathione Peroxidase, and Interlukine-18 in Patients with Essential Hypertension

Salar Fatih Kudhur, Shatha Rouf Moustafa

Published in American Journal of Internal Medicine (Volume 3, Issue 3)

Received: 23 March 2015 Accepted: 1 April 2015 Published: 9 April 2015

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Abstract

Background and objectives: The oxidative stress, antioxidant status and inflammatory process are cooperative events involved in development and progression of essential hypertension. This study was as a step for elucidating the contribution of the malondialdehyde, glutathione peroxidase, interlukine -18 and lipid profile with the incidence, development, and progression of essential hypertension. Aims: The aims of this study were, to assess the change in serum malondialdehyde, glutathione peroxidase, interlukine-18 and lipid profile levels in patients with essential hypertension, moreover, find out the effect of other confounding factors age, gender and stage of the disease on the serum levels of focused parameters and finally detect the correlation between all interested parameters. Patients and Methods: This study was designed to examine the associations between the serum interested parameters levels with the incidence of essential hypertension in 50 patients of both genders, and for the comparing purpose an equal number of the matched age–gender healthy adults also enrolled in this study as a control group. The hypothesis that oxidant /antioxidant status and inflammatory process influence the risk of adverse clinical outcomes are worthy for investigating. Accordingly, malondialdehyde was measured using coloremetric method, while, glutathione peroxidase and interlukine -18 were measured using enzyme linked immmunosorbent assay and lipid profile was estimated using commercial kit. Results: Patients exhibited a significant elevation in the serum malondialdehyde, glutathione peroxidase, interleukin-18 and lipid profile levels as compared with the control group. Conclusion: The data of the present study indicated that an alteration in oxidant / antioxidant status and inflammatory process in patients with essential hypertension. This investigation provided the first evidence of the ability of malondialdehyde, glutathione peroxidase, interlukine -18 and lipid profile in combination patterns as a factors involved in essential hypertension pathophysiology, etiology and are regarded as a markers of prognostic significance and potential therapeutic targets for future. The demonstration of these parameters provided a new insights into understanding the independence of oxidative stress /antioxidant status and inflammatory pathways in essential hypertension incidence, development and progression.

Published in	American Journal of Internal Medicine (Volume 3, Issue 3)
DOI	10.11648/j.ajim.20150303.15
Page(s)	117-126
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Essential Hypertension, Malondialdehyde, Glutathione Peroxidase, Interleukine -18

References

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Salar Fatih Kudhur, Shatha Rouf Moustafa. (2015). The Impact of the Oxidative Stress and Inflammatory Process on the Serum Levels of Malonaldialdehyde, Glutathione Peroxidase, and Interlukine-18 in Patients with Essential Hypertension. American Journal of Internal Medicine, 3(3), 117-126. https://doi.org/10.11648/j.ajim.20150303.15

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Salar Fatih Kudhur; Shatha Rouf Moustafa. The Impact of the Oxidative Stress and Inflammatory Process on the Serum Levels of Malonaldialdehyde, Glutathione Peroxidase, and Interlukine-18 in Patients with Essential Hypertension. Am. J. Intern. Med. 2015, 3(3), 117-126. doi: 10.11648/j.ajim.20150303.15

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AMA Style

Salar Fatih Kudhur, Shatha Rouf Moustafa. The Impact of the Oxidative Stress and Inflammatory Process on the Serum Levels of Malonaldialdehyde, Glutathione Peroxidase, and Interlukine-18 in Patients with Essential Hypertension. Am J Intern Med. 2015;3(3):117-126. doi: 10.11648/j.ajim.20150303.15

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@article{10.11648/j.ajim.20150303.15,
  author = {Salar Fatih Kudhur and Shatha Rouf Moustafa},
  title = {The Impact of the Oxidative Stress and Inflammatory Process on the Serum Levels of Malonaldialdehyde, Glutathione Peroxidase, and Interlukine-18 in Patients with Essential Hypertension},
  journal = {American Journal of Internal Medicine},
  volume = {3},
  number = {3},
  pages = {117-126},
  doi = {10.11648/j.ajim.20150303.15},
  url = {https://doi.org/10.11648/j.ajim.20150303.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20150303.15},
  abstract = {Background and objectives: The oxidative stress, antioxidant status and inflammatory process are cooperative events involved in development and progression of essential hypertension. This study was as a step for elucidating the contribution of the malondialdehyde, glutathione peroxidase, interlukine -18 and lipid profile with the incidence, development, and progression of essential hypertension. Aims: The aims of this study were, to assess the change in serum malondialdehyde, glutathione peroxidase, interlukine-18 and lipid profile levels in patients with essential hypertension, moreover, find out the effect of other confounding factors age, gender and stage of the disease on the serum levels of focused parameters and finally detect the correlation between all interested parameters. Patients and Methods: This study was designed to examine the associations between the serum interested parameters levels with the incidence of essential hypertension in 50 patients of both genders, and for the comparing purpose an equal number of the matched age–gender healthy adults also enrolled in this study as a control group. The hypothesis that oxidant /antioxidant status and inflammatory process influence the risk of adverse clinical outcomes are worthy for investigating. Accordingly, malondialdehyde was measured using coloremetric method, while, glutathione peroxidase and interlukine -18 were measured using enzyme linked immmunosorbent assay and lipid profile was estimated using commercial kit. Results: Patients exhibited a significant elevation in the serum malondialdehyde, glutathione peroxidase, interleukin-18 and lipid profile levels as compared with the control group. Conclusion: The data of the present study indicated that an alteration in oxidant / antioxidant status and inflammatory process in patients with essential hypertension. This investigation provided the first evidence of the ability of malondialdehyde, glutathione peroxidase, interlukine -18 and lipid profile in combination patterns as a factors involved in essential hypertension pathophysiology, etiology and are regarded as a markers of prognostic significance and potential therapeutic targets for future. The demonstration of these parameters provided a new insights into understanding the independence of oxidative stress /antioxidant status and inflammatory pathways in essential hypertension incidence, development and progression.},
 year = {2015}
}

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TY  - JOUR
T1  - The Impact of the Oxidative Stress and Inflammatory Process on the Serum Levels of Malonaldialdehyde, Glutathione Peroxidase, and Interlukine-18 in Patients with Essential Hypertension
AU  - Salar Fatih Kudhur
AU  - Shatha Rouf Moustafa
Y1  - 2015/04/09
PY  - 2015
N1  - https://doi.org/10.11648/j.ajim.20150303.15
DO  - 10.11648/j.ajim.20150303.15
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 117
EP  - 126
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.20150303.15
AB  - Background and objectives: The oxidative stress, antioxidant status and inflammatory process are cooperative events involved in development and progression of essential hypertension. This study was as a step for elucidating the contribution of the malondialdehyde, glutathione peroxidase, interlukine -18 and lipid profile with the incidence, development, and progression of essential hypertension. Aims: The aims of this study were, to assess the change in serum malondialdehyde, glutathione peroxidase, interlukine-18 and lipid profile levels in patients with essential hypertension, moreover, find out the effect of other confounding factors age, gender and stage of the disease on the serum levels of focused parameters and finally detect the correlation between all interested parameters. Patients and Methods: This study was designed to examine the associations between the serum interested parameters levels with the incidence of essential hypertension in 50 patients of both genders, and for the comparing purpose an equal number of the matched age–gender healthy adults also enrolled in this study as a control group. The hypothesis that oxidant /antioxidant status and inflammatory process influence the risk of adverse clinical outcomes are worthy for investigating. Accordingly, malondialdehyde was measured using coloremetric method, while, glutathione peroxidase and interlukine -18 were measured using enzyme linked immmunosorbent assay and lipid profile was estimated using commercial kit. Results: Patients exhibited a significant elevation in the serum malondialdehyde, glutathione peroxidase, interleukin-18 and lipid profile levels as compared with the control group. Conclusion: The data of the present study indicated that an alteration in oxidant / antioxidant status and inflammatory process in patients with essential hypertension. This investigation provided the first evidence of the ability of malondialdehyde, glutathione peroxidase, interlukine -18 and lipid profile in combination patterns as a factors involved in essential hypertension pathophysiology, etiology and are regarded as a markers of prognostic significance and potential therapeutic targets for future. The demonstration of these parameters provided a new insights into understanding the independence of oxidative stress /antioxidant status and inflammatory pathways in essential hypertension incidence, development and progression.
VL  - 3
IS  - 3
ER  -

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Salar Fatih Kudhur

Ministry of Health, Psychiatric Hospital, Head of Pharmacy Department, Havalan city, Erbil, Iraq, Kurdish
Shatha Rouf Moustafa

College of Pharmacy, Hawler Medical University, Havalan city, Erbil, Iraq, Arabian

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Salar Fatih Kudhur, Shatha Rouf Moustafa. (2015). The Impact of the Oxidative Stress and Inflammatory Process on the Serum Levels of Malonaldialdehyde, Glutathione Peroxidase, and Interlukine-18 in Patients with Essential Hypertension. American Journal of Internal Medicine, 3(3), 117-126. https://doi.org/10.11648/j.ajim.20150303.15

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Salar Fatih Kudhur; Shatha Rouf Moustafa. The Impact of the Oxidative Stress and Inflammatory Process on the Serum Levels of Malonaldialdehyde, Glutathione Peroxidase, and Interlukine-18 in Patients with Essential Hypertension. Am. J. Intern. Med. 2015, 3(3), 117-126. doi: 10.11648/j.ajim.20150303.15

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AMA Style

Salar Fatih Kudhur, Shatha Rouf Moustafa. The Impact of the Oxidative Stress and Inflammatory Process on the Serum Levels of Malonaldialdehyde, Glutathione Peroxidase, and Interlukine-18 in Patients with Essential Hypertension. Am J Intern Med. 2015;3(3):117-126. doi: 10.11648/j.ajim.20150303.15

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@article{10.11648/j.ajim.20150303.15,
  author = {Salar Fatih Kudhur and Shatha Rouf Moustafa},
  title = {The Impact of the Oxidative Stress and Inflammatory Process on the Serum Levels of Malonaldialdehyde, Glutathione Peroxidase, and Interlukine-18 in Patients with Essential Hypertension},
  journal = {American Journal of Internal Medicine},
  volume = {3},
  number = {3},
  pages = {117-126},
  doi = {10.11648/j.ajim.20150303.15},
  url = {https://doi.org/10.11648/j.ajim.20150303.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20150303.15},
  abstract = {Background and objectives: The oxidative stress, antioxidant status and inflammatory process are cooperative events involved in development and progression of essential hypertension. This study was as a step for elucidating the contribution of the malondialdehyde, glutathione peroxidase, interlukine -18 and lipid profile with the incidence, development, and progression of essential hypertension. Aims: The aims of this study were, to assess the change in serum malondialdehyde, glutathione peroxidase, interlukine-18 and lipid profile levels in patients with essential hypertension, moreover, find out the effect of other confounding factors age, gender and stage of the disease on the serum levels of focused parameters and finally detect the correlation between all interested parameters. Patients and Methods: This study was designed to examine the associations between the serum interested parameters levels with the incidence of essential hypertension in 50 patients of both genders, and for the comparing purpose an equal number of the matched age–gender healthy adults also enrolled in this study as a control group. The hypothesis that oxidant /antioxidant status and inflammatory process influence the risk of adverse clinical outcomes are worthy for investigating. Accordingly, malondialdehyde was measured using coloremetric method, while, glutathione peroxidase and interlukine -18 were measured using enzyme linked immmunosorbent assay and lipid profile was estimated using commercial kit. Results: Patients exhibited a significant elevation in the serum malondialdehyde, glutathione peroxidase, interleukin-18 and lipid profile levels as compared with the control group. Conclusion: The data of the present study indicated that an alteration in oxidant / antioxidant status and inflammatory process in patients with essential hypertension. This investigation provided the first evidence of the ability of malondialdehyde, glutathione peroxidase, interlukine -18 and lipid profile in combination patterns as a factors involved in essential hypertension pathophysiology, etiology and are regarded as a markers of prognostic significance and potential therapeutic targets for future. The demonstration of these parameters provided a new insights into understanding the independence of oxidative stress /antioxidant status and inflammatory pathways in essential hypertension incidence, development and progression.},
 year = {2015}
}

Copy | Download

TY  - JOUR
T1  - The Impact of the Oxidative Stress and Inflammatory Process on the Serum Levels of Malonaldialdehyde, Glutathione Peroxidase, and Interlukine-18 in Patients with Essential Hypertension
AU  - Salar Fatih Kudhur
AU  - Shatha Rouf Moustafa
Y1  - 2015/04/09
PY  - 2015
N1  - https://doi.org/10.11648/j.ajim.20150303.15
DO  - 10.11648/j.ajim.20150303.15
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 117
EP  - 126
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.20150303.15
AB  - Background and objectives: The oxidative stress, antioxidant status and inflammatory process are cooperative events involved in development and progression of essential hypertension. This study was as a step for elucidating the contribution of the malondialdehyde, glutathione peroxidase, interlukine -18 and lipid profile with the incidence, development, and progression of essential hypertension. Aims: The aims of this study were, to assess the change in serum malondialdehyde, glutathione peroxidase, interlukine-18 and lipid profile levels in patients with essential hypertension, moreover, find out the effect of other confounding factors age, gender and stage of the disease on the serum levels of focused parameters and finally detect the correlation between all interested parameters. Patients and Methods: This study was designed to examine the associations between the serum interested parameters levels with the incidence of essential hypertension in 50 patients of both genders, and for the comparing purpose an equal number of the matched age–gender healthy adults also enrolled in this study as a control group. The hypothesis that oxidant /antioxidant status and inflammatory process influence the risk of adverse clinical outcomes are worthy for investigating. Accordingly, malondialdehyde was measured using coloremetric method, while, glutathione peroxidase and interlukine -18 were measured using enzyme linked immmunosorbent assay and lipid profile was estimated using commercial kit. Results: Patients exhibited a significant elevation in the serum malondialdehyde, glutathione peroxidase, interleukin-18 and lipid profile levels as compared with the control group. Conclusion: The data of the present study indicated that an alteration in oxidant / antioxidant status and inflammatory process in patients with essential hypertension. This investigation provided the first evidence of the ability of malondialdehyde, glutathione peroxidase, interlukine -18 and lipid profile in combination patterns as a factors involved in essential hypertension pathophysiology, etiology and are regarded as a markers of prognostic significance and potential therapeutic targets for future. The demonstration of these parameters provided a new insights into understanding the independence of oxidative stress /antioxidant status and inflammatory pathways in essential hypertension incidence, development and progression.
VL  - 3
IS  - 3
ER  -

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