Background: Prevention, monitoring and reporting of adverse drug reactions is still a challenge among Nurses. Objective: to assess predictors of Nurses’ practice related to adverse drug reaction reporting at Felegehiwot Referral Hospital and University of Gondar Teaching Hospital, Northwest Ethiopia. Method: Hospital based cross sectional study was conducted at Felegehiwot Referral Hospital and University of Gondar Teaching Hospital from March 11, 2013 to April 12, 2013. A total number of 214 Nurses involved in this study. Self-administered pre-tested questionnaire was used. Stratified random sampling technique was used to select study participants. Bivariate analysis and multivariable logistic regression analyses were employed for identifying not reporting practice regarding adverse drug reaction. Results: Mean age of the respondents 21.8 years (SD = 7.01). One hundred twenty two (57.0%) of the respondents were females, 152(71.7%) participants’ level of education were bachelor of Nurse. The participants mean of experience were 1.64 (SD = 4.7) years. Participants who took training/seminar on Pharmacovigilance had 0.29 times more likely to have adequate knowledge (AOR = 0.29, 95% CI = 0.226– 0.004, P=0.001) Conclusions and recommendation: Even though most Nurses had encountered adverse drug reaction, most of them were not reporting regarding adverse drug reaction. So Food, Medicine, Health Care Administration and Control Authority of Ethiopia should prepare training and continual education related to adverse drug reaction reporting for Nurses.
| Published in | American Journal of Health Research (Volume 2, Issue 4) |
| DOI | 10.11648/j.ajhr.20140204.27 |
| Page(s) | 207-215 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2014. Published by Science Publishing Group |
Factor, Practice, Pharmacovigilance, Ethiopia
| [1] | New rules for reporting in European union, Article 114 and Article 168(4)(c) (2010). |
| [2] | Organisation WH. The Safety of Medicines in Public Health Programmes. Geneva, Switzerland:: The Uppsala Monitoring Centre2006. |
| [3] | Patel KJ, Kedia MS, Bajpai D, Mehta SS, Kshirsagar NA, Gogtay NJ. Evaluation of the prevalence and economic burden of adverse drug reactions presenting to the medical emergency department of a tertiary referral centre: a prospective study. BMC Clin Pharmacol. 2007;7:8. |
| [4] | RA. K. Adverse drug reaction may be a leading cause of death in US. 1998. |
| [5] | Wester K, Jonsson AK, Spigset O, Druid H, Hagg S. Incidence of fatal adverse drug reactions: a population based study. Br J Clin Pharmacol. 2008 Apr;65(4):573-9. |
| [6] | Mehta U, Durrheim DN, Blockman M, Kredo T, Gounden R, Barnes KI. Adverse drug reactions in adult medical inpatients in a South African hospital serving a community with a high HIV/AIDS prevalence: prospective observational study. Br J Clin Pharmacol. 2008 Mar;65(3):396-406. |
| [7] | Dawit Dilbato ZG, Shiferaw Teklemariam. A base line survey on prescribibng indicators and factors influencing prescribing in Southern Ethiopia. Ethiop J Health Dev. 1998;12(2):87-93. |
| [8] | Pirmohamed M, Atuah KN, Dodoo AN, Winstanley P. Pharmacovigilance in developing countries. BMJ. 2007 Sep 8;335(7618):462. |
| [9] | Aklillu E, Persson I, Bertilsson L, Johansson I, Rodrigues F, Ingelman-Sundberg M. Frequent distribution of ultrarapid metabolizers of debrisoquine in an ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles. J Pharmacol Exp Ther. 1996 Jul;278(1):441-6. |
| [10] | Organization WH. A Guideline to detecting and reporting adverse drug reactions. Swizerland,Geneva2001. |
| [11] | Wallenstein EJ FD. Temporal patterns of NSAID spontaneous adverse event reports. Drug Safe. 2001; 24(3):233-7. |
| [12] | McAdams MA GL, Swartz L, Hammad TA, Dal Pan GJ. Identifying patterns of adverse event reporting for four members of the angiotensin II receptor blockers class of drugs ;revisiting the Weber effect. Pharmacoepidemiol Drug Saf. 2008;17(9):882-9. |
| [13] | Chen Y LS, Yao LS, Wang R, Dai YT. Valsartan treatment reverses erectile dysfunction in diabetic rats. Int J Impot Res 2007;19(4):366-70. |
| [14] | Andrea Kuemmerle AND, Sten Olsson, Jan Van Erps, Christian Burri, Paul S Lalvani. Assessment of global reporting of adverse drug reactions for anti-malarials, including artemisininbased combination therapy, to the WHO Programme for International Drug Monitoring. Biomed central of malaria journal. [Open Access]. 2013;10:57:1-10. |
| [15] | Pal DS. Africa pharmacovigiliance meeting. Kenya: WHO2013. |
| [16] | plus/SPS DAaCAicwMR. Report on the assessment of health care providers’ knowledge, attitude and practice on Adverse Drug Reaction (adverse drug reaction) reporting and its monitoring. Addis Ababa, Ethiopia: DACAAugust, 2008. |
| [17] | Mulugeta T.Angamo AT, Nasir Tajure Wabe. Knowledge, Attitude and Practice of Adverse Drug Reaction Reporting among Health Professionals in Southwest Ethiopia]. TAF Prev Med Bull. .2011;23.11.2011:1-10. |
| [18] | Figueiras A HM, Polonia J, Gestal-Otero JJ. An educational intervention to improve physician reporting of adverse drug reactions: a cluster-randomized controlled trial. JAMA. 2006;296:1086-93. |
| [19] | Pedros C, Vallano A, Cereza G, Mendoza-Aran G, Agusti A, Aguilera C, et al. An intervention to improve spontaneous adverse drug reaction reporting by hospital physicians: a time series analysis in Spain. Drug Saf. 2009;32(1):77-83. |
| [20] | Cosentino M, Leoni O, Banfi F, Lecchini S, Frigo G. Attitudes to adverse drug reaction reporting by medical practitioners in a Northern Italian district. Pharmacol Res. 1997 Feb;35(2):85-8. |
| [21] | Scott HD T-RA, Rosenbaum SE, et al. Physician reporting of adverse drug reactions: results of the Rhode Island Adverse Drug Reaction Reporting Project. JAMA 1990;263:1785–8. |
| [22] | Hossein Khalili NM, 1 Narjes Hendoiee, Abbas-Ali Keshtkar,Simin Dashti-Khavidaki. Improvement of knowledge, attitude and perception of healthcare workers about adverse drug reaction, a pre- and post-clinical pharmacists’ interventional study. bmjopen. September ,2011:1-7. |
| [23] | Radhakrishnan Rajesh SV, Danturulu Muralidhar Varma. An Educational Intervention to assess Knowledge Attitude Practice of pharmacovigilance among Health care professionals in an Indian tertiary care teaching hospital. International Journal of PharmTech Research. 2011;3(2): 678-92. |
| [24] | Li Q, Zhang SM, Chen HT, Fang SP, Yu X, Liu D, et al. Awareness and attitudes of healthcare professionals in Wuhan, China to the reporting of adverse drug reactions. Chin Med J (Engl). 2004 Jun;117(6):856-61. |
| [25] | Nagpure Shailesh KR, Varma Sushil Kumar,Bahekar Satish. Impact of Educational Intervention on Knowledge, Attitude and Practice of Pharmacovigilance among Medical Graduates of Rural Tertiary Care, Teaching Hospital Of Central India. Mintage journal of pharmaceutical and medical sciences. 04-04-2013:51-4. |
| [26] | plus/SPS DAaCAicwMR. Report on the assessment of health care providers’ knowledge, attitude and practice on Adverse Drug Reaction (adverse drug reaction) reporting and its monitoring 2008. |
| [27] | Paul Gavaza CMB, Kenneth A. Lawson, Karen L. Rascati, James P. Wilson, and Mary Steinhardt. Texas pharmacists’ knowledge of reporting serious adverse drug events to the Food and Drug Administration. J Am Pharm Assoc. 2011;51:397–403. |
| [28] | Toklu HZ, Uysal MK. The knowledge and attitude of the Turkish community pharmacists toward pharmacovigilance in the Kadikoy district of Istanbul. Pharm World Sci. 2008 Oct;30(5):556-62. |
| [29] | Sweis D, Wong IC. A survey on factors that could affect adverse drug reaction reporting according to hospital pharmacists in Great Britain. Drug Saf. 2000 Aug;23(2):165-72. |
| [30] | Green CF MD, Rowe PH, Pirmohamed M. Attitudes and knowledge of hospital pharmacists to adverse drug reaction reporting. Br J Clin Pharmacol. 2001;51(1):81-6. |
| [31] | Lee KK CT, Raymond K. Pharmacists’ attitudes toward adverse drug reactions reporting in Hong Kong. Ann Pharmacother 1994;28:1400-3. |
| [32] | . Generali JA DM, Rosenbaum SE. of and attitudes about adverse drug reaction reporting among Rhode Island pharmacists. Ann Pharmacother. 1995;29:365-9. |
| [33] | Evans SM, Berry JG, Smith BJ, Esterman A, Selim P, O'Shaughnessy J, et al. Attitudes and barriers to incident reporting: a collaborative hospital study. Qual Saf Health Care. 2006 Feb;15(1):39-43. |
| [34] | Bateman DN SG, Rawlins MD. Attitudes to adverse drug reaction reporting in the Northern Region. Br J Clin Pharmacol 1992;34:421-6. |
| [35] | Eland IA BK, van Grootheest AC, Meiners AP, Rawlins MD, Stricker BH. Attitudinal survey of voluntary reporting of adverse drug reactions. NBr J Clin Pharmacol. 1999 48:623-7. |
| [36] | Belton KJ LS, Payne S. Attitudinal survey of adverse drug reaction reporting by medical practitioners in the United Kingdom. Br J Clin Pharmacol 1995;39:223-6. |
| [37] | Ba¨ckstro¨m M MT, Dahlqvist R. Attitudes to reporting adverse drug reaction in northern Sweden. Eur J Clin Pharmacol 2000;56:729-32. |
| [38] | McGettigan P FJ. adverse drug reaction reporting opinions and attitudes of medical practitioners in Ireland. Pharmacoepidemiol Drug Saf 1995:4:355-8. |
| [39] | Belton KJ TEPRG. Attitude survey of adverse drug-reaction reporting by health care professionals across the European Union. Eur J Clin Pharmacol 1997;52:423-7. |
| [40] | Lopez-Gonzalez E HM, Figueiras A. Determinants of under-reporting of adverse drug reactions: a systematic review. Drug Saf 2009 32:19-31. |
| [41] | Williams D FJ. Underreporting of adverse drug reactions: attitudes of Irish doctors. Ir J Med Sci 1999;168:257-61. |
| [42] | Hazell L SS. Under-reporting of adverse drug reactions: a systematic review. Drug Saf 2006;29:385-96. |
| [43] | Nichols V T-DI, Touzin J, Delisle JF, Lebel D, Bussières JF, Bailey B, Collin J. . Risk perception and reasons for noncompliance in pharmacovigilance: a qualitative study conducted in Canada. Drug Saf 2009;32:579-90. |
| [44] | Oshikoya KA, Awobusuyi JO. Perceptions of doctors to adverse drug reaction reporting in a teaching hospital in Lagos, Nigeria. BMC Clin Pharmacol. 2009;9:14. |
| [45] | Kelly M KKaDS. Factors influencing adverse drug reaction reporting in New South Wales teaching hospitals. J Pharm Practice Res. 2004;34:32–5. |
| [46] | Belton KJ, Lewis SC, Payne S, Rawlins MD, Wood SM. Attitudinal survey of adverse drug reaction reporting by medical practitioners in the United Kingdom. Br J Clin Pharmacol. 1995 Mar;39(3):223-6. |
| [47] | JA. V. Adverse drug reaction surveillance: practical methods for developing a successful monitoring program. 2000. |
| [48] | RAJESH A KAMTANE VJ. Knowledge, Attitude and Perception of Physicians towards Adverse Drug Reaction Reporting: A Pharmaco-epidemiological Study. Asian J Pharm Clin Res. [Academic Sciences]. 2012;5(3). |
| [49] | Bäckström M MT. A small economic inducement to stimulate increased reporting of adverse drug reactions--a way of dealing with an old problem? . Eur J Clin Pharmacol 2006;62:381-5. |
APA Style
Abewa Adimasu. (2014). Predictors of Nurses Reporting Practice Related to Adverse Drug Reaction at Felegehiwot Referral Hospital and Felegehiwot Referral Hospital and University of Gondar Teaching Hospital, Northwest Ethiopia. American Journal of Health Research, 2(4), 207-215. https://doi.org/10.11648/j.ajhr.20140204.27
ACS Style
Abewa Adimasu. Predictors of Nurses Reporting Practice Related to Adverse Drug Reaction at Felegehiwot Referral Hospital and Felegehiwot Referral Hospital and University of Gondar Teaching Hospital, Northwest Ethiopia. Am. J. Health Res. 2014, 2(4), 207-215. doi: 10.11648/j.ajhr.20140204.27
AMA Style
Abewa Adimasu. Predictors of Nurses Reporting Practice Related to Adverse Drug Reaction at Felegehiwot Referral Hospital and Felegehiwot Referral Hospital and University of Gondar Teaching Hospital, Northwest Ethiopia. Am J Health Res. 2014;2(4):207-215. doi: 10.11648/j.ajhr.20140204.27
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Download@article{10.11648/j.ajhr.20140204.27,
author = {Abewa Adimasu},
title = {Predictors of Nurses Reporting Practice Related to Adverse Drug Reaction at Felegehiwot Referral Hospital and Felegehiwot Referral Hospital and University of Gondar Teaching Hospital, Northwest Ethiopia},
journal = {American Journal of Health Research},
volume = {2},
number = {4},
pages = {207-215},
doi = {10.11648/j.ajhr.20140204.27},
url = {https://doi.org/10.11648/j.ajhr.20140204.27},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhr.20140204.27},
abstract = {Background: Prevention, monitoring and reporting of adverse drug reactions is still a challenge among Nurses. Objective: to assess predictors of Nurses’ practice related to adverse drug reaction reporting at Felegehiwot Referral Hospital and University of Gondar Teaching Hospital, Northwest Ethiopia. Method: Hospital based cross sectional study was conducted at Felegehiwot Referral Hospital and University of Gondar Teaching Hospital from March 11, 2013 to April 12, 2013. A total number of 214 Nurses involved in this study. Self-administered pre-tested questionnaire was used. Stratified random sampling technique was used to select study participants. Bivariate analysis and multivariable logistic regression analyses were employed for identifying not reporting practice regarding adverse drug reaction. Results: Mean age of the respondents 21.8 years (SD = 7.01). One hundred twenty two (57.0%) of the respondents were females, 152(71.7%) participants’ level of education were bachelor of Nurse. The participants mean of experience were 1.64 (SD = 4.7) years. Participants who took training/seminar on Pharmacovigilance had 0.29 times more likely to have adequate knowledge (AOR = 0.29, 95% CI = 0.226– 0.004, P=0.001) Conclusions and recommendation: Even though most Nurses had encountered adverse drug reaction, most of them were not reporting regarding adverse drug reaction. So Food, Medicine, Health Care Administration and Control Authority of Ethiopia should prepare training and continual education related to adverse drug reaction reporting for Nurses.},
year = {2014}
}
TY - JOUR T1 - Predictors of Nurses Reporting Practice Related to Adverse Drug Reaction at Felegehiwot Referral Hospital and Felegehiwot Referral Hospital and University of Gondar Teaching Hospital, Northwest Ethiopia AU - Abewa Adimasu Y1 - 2014/08/30 PY - 2014 N1 - https://doi.org/10.11648/j.ajhr.20140204.27 DO - 10.11648/j.ajhr.20140204.27 T2 - American Journal of Health Research JF - American Journal of Health Research JO - American Journal of Health Research SP - 207 EP - 215 PB - Science Publishing Group SN - 2330-8796 UR - https://doi.org/10.11648/j.ajhr.20140204.27 AB - Background: Prevention, monitoring and reporting of adverse drug reactions is still a challenge among Nurses. Objective: to assess predictors of Nurses’ practice related to adverse drug reaction reporting at Felegehiwot Referral Hospital and University of Gondar Teaching Hospital, Northwest Ethiopia. Method: Hospital based cross sectional study was conducted at Felegehiwot Referral Hospital and University of Gondar Teaching Hospital from March 11, 2013 to April 12, 2013. A total number of 214 Nurses involved in this study. Self-administered pre-tested questionnaire was used. Stratified random sampling technique was used to select study participants. Bivariate analysis and multivariable logistic regression analyses were employed for identifying not reporting practice regarding adverse drug reaction. Results: Mean age of the respondents 21.8 years (SD = 7.01). One hundred twenty two (57.0%) of the respondents were females, 152(71.7%) participants’ level of education were bachelor of Nurse. The participants mean of experience were 1.64 (SD = 4.7) years. Participants who took training/seminar on Pharmacovigilance had 0.29 times more likely to have adequate knowledge (AOR = 0.29, 95% CI = 0.226– 0.004, P=0.001) Conclusions and recommendation: Even though most Nurses had encountered adverse drug reaction, most of them were not reporting regarding adverse drug reaction. So Food, Medicine, Health Care Administration and Control Authority of Ethiopia should prepare training and continual education related to adverse drug reaction reporting for Nurses. VL - 2 IS - 4 ER -
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