Age-Dependent Change in Aldo-Keto Reductases Composition in the Blood of Rats

Vadim Vyacheslavovich Davydov; Anatoliy Ivanovich Bozhkov; Evgeniya Romanovna Grabovetskaya

doi:doi:10.11648/j.ajbls.s.2014020601.11

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Age-Dependent Change in Aldo-Keto Reductases Composition in the Blood of Rats

Vadim Vyacheslavovich Davydov, Anatoliy Ivanovich Bozhkov, Evgeniya Romanovna Grabovetskaya

Published in American Journal of Biomedical and Life Sciences (Volume 2, Issue 6-1)

Received: 3 August 2014 Accepted: 6 August 2014 Published: 13 August 2014

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Abstract

Resistance of the organism to the stress injury changes during ontogenesis. In this regard, the incidence of cardiovascular, central nervous, endocrine systems, etc. increases at certain stages of individual development. Taking into account the fact that the development of stress-caused lesions is associated with accumulation of carbonyl products of free radical oxidation in cells, we have suggested that the one of the reasons for this phenomenon is age-related changes in the efficiency of the scavenging of endogenous aldehydes in the organism. In view of this fact, spectrum of aldo-keto reductases in blood serum of rats at different stages of ontogenesis was investigated by means of electrophoresis. Identical changes in the composition of aldo-keto reductases spectrum of blood in early immature age and in aging have been shown. Change in aldo-keto reductases spectrum modulates the role of reductive pathway of endogenous aldehydes scavenging in the organism. Thus, in child age and aging efficiency of scavenging of carbonyl products of free radical oxidation in cells is limited and especially when they are intensively produced. This results in increase of the susceptibility of the organism to oxidative stress.

Published in	American Journal of Biomedical and Life Sciences (Volume 2, Issue 6-1) This article belongs to the Special Issue Mechanisms of Protection Against Oxidative Stress
DOI	10.11648/j.ajbls.s.2014020601.11
Page(s)	1-4
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Aldo-Keto Reductases, Blood, Ontogenesis, Oxidative Stress, Stress

References

[1]	Li J. and Holbrook N.J. (2003) Common mechanisms for declines in oxidative stress tolerance and proliferation with aging. Free Radical. Biol. Med, 35, 292 – 299.
[2]	Volkova Yu.V. et al. (2011) Activity of the first line antioxidant defense enzymes in the liver of pubertal rats during stress. Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, 5, 389 – 391.
[3]	Davydov V.V. and Shvets V.N. (2007) Lipid peroxidation in the heart of adult and old rats during immobilization stress. Exp.Gerontol, 5, 1155 – 1160.
[4]	Saner H. (2005) Stress as a cardiovascular risk factor. Ther. Umsch, 62, 597–602.
[5]	Giallauria F. et al. (2007) Psychosocial risk factors in cardiac practice. Monaldi Arch. Chest Dis, 68, 74–80.
[6]	Nayanatara A.K., Nagaraja H.S. and Anupama B.K. (2005) The effect of repeated swimming stress on organ weights and lipid peroxidation in rats. Thai J. Physiol. Sci, 18, 3 – 9.
[7]	Sahin E. and Gumuslu S. (2007) Immobilization stress in rat tissues: alteration of protein oxidation, lipid peroxidation and antioxidant defense system. Comp. Biochem. Physiol. C. Toxicol. Pharmacol, 144, 324 – 347.
[8]	Uchida K. (2000) Role of reactive aldehyde in cardiovascular disease. Free Radical. Biol. Med, 28, 1685 – 1696.
[9]	Davydov V.V., Dobaeva N.M. and Bozhkov A.I. (2004) Possible role of aldehyde,s scavenger enzymes during aging. Exp. Gerontol, 39, 11– 16.
[10]	Stone M.P. et al. (2008) Interstrand DNA cross-links induced by ,-unsaturated aldehyde-derived from lipid peroxidation and environmental sources. Acc. Chem. Res, 41, 793 – 804.
[11]	Davydov V.V., Bozhkov A.I. and Kulchitski O.K. (2012) Physiological and pathophysiological role of endogenous aldehydes,– Saarbrucken: Palmarium Academic Publishing, 240. (in Russian).
[12]	Srivastava S. et al. (1998) Metabolism of the Lipid Peroxidation Product, 4-Hydroxy-trans-2-nonenal, in Isolated Perfused Rat Hear. J. Biol. Chem, 273, 10893 – 10900.
[13]	O’Brein P.J.O., Siraki A. G. and Shangari N. (2005) Aldehyde sources metabolism, molecular toxicity mechanisms, and possible effects on human health. Critical Reviews in Toxicology, 35, 609 – 662.
[14]	Esterbauer H., Zollner H. and Lang J. (1985) Metabolism of the lipid peroxidation product 4-hydroxynonenal by isolated hepatocytes and by liver cytosolic fractions. Biochem. J, 228, 363 – 373.
[15]	Kawasaki N., Tanimoto T. and Tanaka A. (1989) Aldose reductase and aldehyde reductase from mammals. Biochim. Biophys. Acta, 996, 30 – 36.
[16]	Srivastava S. et al. (1998) Identification of cardiac oxidoreductase (s) involved in the metabolism of the lipid peroxidation-derived aldehyde 4-hydroxynonenal. Biochem. J, 329, 469 – 475.
[17]	Ramana K. V. et al. (2000) Selective recognition of glutathiolated aldehydes by aldose reductase. Biochemistry, 39, 12172 – 12180.
[18]	Jez J.M. et al. (1997) Comparative anatomy of the aldo-keto reductase superfamily. Biochem. J, 326, 625 – 636.
[19]	Nihmat A.M. and Flynn T.G. (1989) Aldose reductase from human psoas muscle. J. Biol. Chem, 264, 2906 – 2911.
[20]	Barski O.A. et al. (1995) Mechanism of human aldehyde reductase: characterization of the active site pocket. Biochemisty, 34, 11264 – 11275.
[21]	Srivastava S. et al. (2001) Structural and kinetic modifications of aldose reductase by S-nitrosothiols. J. Biol. Chem, 358, 11 – 118.
[22]	Lakatta E. G. (2001) Heart aging: a fly in the ointment. Circ. Res, 88, 984 – 986.
[23]	Docherty I. R. (1990) Cardiovascular responses in aging. Pharmacol. Rev, 42, 103 –126.
[24]	Davydov V.V. and Grabovetskaya E.R. (2014) Interrelationship between testosterone level and aldo-keto reductase activity in the blood of different ages rats. Advances in Biological Chemistry, 2, 40 – 44.

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Vadim Vyacheslavovich Davydov, Anatoliy Ivanovich Bozhkov, Evgeniya Romanovna Grabovetskaya. (2014). Age-Dependent Change in Aldo-Keto Reductases Composition in the Blood of Rats. American Journal of Biomedical and Life Sciences, 2(6-1), 1-4. https://doi.org/10.11648/j.ajbls.s.2014020601.11

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ACS Style

Vadim Vyacheslavovich Davydov; Anatoliy Ivanovich Bozhkov; Evgeniya Romanovna Grabovetskaya. Age-Dependent Change in Aldo-Keto Reductases Composition in the Blood of Rats. Am. J. Biomed. Life Sci. 2014, 2(6-1), 1-4. doi: 10.11648/j.ajbls.s.2014020601.11

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AMA Style

Vadim Vyacheslavovich Davydov, Anatoliy Ivanovich Bozhkov, Evgeniya Romanovna Grabovetskaya. Age-Dependent Change in Aldo-Keto Reductases Composition in the Blood of Rats. Am J Biomed Life Sci. 2014;2(6-1):1-4. doi: 10.11648/j.ajbls.s.2014020601.11

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@article{10.11648/j.ajbls.s.2014020601.11,
  author = {Vadim Vyacheslavovich Davydov and Anatoliy Ivanovich Bozhkov and Evgeniya Romanovna Grabovetskaya},
  title = {Age-Dependent Change in Aldo-Keto Reductases Composition in the Blood of Rats},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {2},
  number = {6-1},
  pages = {1-4},
  doi = {10.11648/j.ajbls.s.2014020601.11},
  url = {https://doi.org/10.11648/j.ajbls.s.2014020601.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.s.2014020601.11},
  abstract = {Resistance of the organism to the stress injury changes during ontogenesis. In this regard, the incidence of cardiovascular, central nervous, endocrine systems, etc. increases at certain stages of individual development. Taking into account the fact that the development of stress-caused lesions is associated with accumulation of carbonyl products of free radical oxidation in cells, we have suggested that the one of the reasons for this phenomenon is age-related changes in the efficiency of the scavenging of endogenous aldehydes in the organism. In view of this fact, spectrum of aldo-keto reductases in blood serum of rats at different stages of ontogenesis was investigated by means of electrophoresis. Identical changes in the composition of aldo-keto reductases spectrum of blood in early immature age and in aging have been shown. Change in aldo-keto reductases spectrum modulates the role of reductive pathway of endogenous aldehydes scavenging in the organism. Thus, in child age and aging efficiency of scavenging of carbonyl products of free radical oxidation in cells is limited and especially when they are intensively produced. This results in increase of the susceptibility of the organism to oxidative stress.},
 year = {2014}
}

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TY  - JOUR
T1  - Age-Dependent Change in Aldo-Keto Reductases Composition in the Blood of Rats
AU  - Vadim Vyacheslavovich Davydov
AU  - Anatoliy Ivanovich Bozhkov
AU  - Evgeniya Romanovna Grabovetskaya
Y1  - 2014/08/13
PY  - 2014
N1  - https://doi.org/10.11648/j.ajbls.s.2014020601.11
DO  - 10.11648/j.ajbls.s.2014020601.11
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 1
EP  - 4
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.s.2014020601.11
AB  - Resistance of the organism to the stress injury changes during ontogenesis. In this regard, the incidence of cardiovascular, central nervous, endocrine systems, etc. increases at certain stages of individual development. Taking into account the fact that the development of stress-caused lesions is associated with accumulation of carbonyl products of free radical oxidation in cells, we have suggested that the one of the reasons for this phenomenon is age-related changes in the efficiency of the scavenging of endogenous aldehydes in the organism. In view of this fact, spectrum of aldo-keto reductases in blood serum of rats at different stages of ontogenesis was investigated by means of electrophoresis. Identical changes in the composition of aldo-keto reductases spectrum of blood in early immature age and in aging have been shown. Change in aldo-keto reductases spectrum modulates the role of reductive pathway of endogenous aldehydes scavenging in the organism. Thus, in child age and aging efficiency of scavenging of carbonyl products of free radical oxidation in cells is limited and especially when they are intensively produced. This results in increase of the susceptibility of the organism to oxidative stress.
VL  - 2
IS  - 6-1
ER  -

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Author Information

Vadim Vyacheslavovich Davydov

State Institution "Institute of Children and Adolescent Health NAMS of Ukraine", Kharkov, Ukraine
Anatoliy Ivanovich Bozhkov

V. N. Karazin Kharkov National University, Kharkov, Ukraine
Evgeniya Romanovna Grabovetskaya

Kharkov National Medical University, Kharkov, Ukraine

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APA Style

Vadim Vyacheslavovich Davydov, Anatoliy Ivanovich Bozhkov, Evgeniya Romanovna Grabovetskaya. (2014). Age-Dependent Change in Aldo-Keto Reductases Composition in the Blood of Rats. American Journal of Biomedical and Life Sciences, 2(6-1), 1-4. https://doi.org/10.11648/j.ajbls.s.2014020601.11

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ACS Style

Vadim Vyacheslavovich Davydov; Anatoliy Ivanovich Bozhkov; Evgeniya Romanovna Grabovetskaya. Age-Dependent Change in Aldo-Keto Reductases Composition in the Blood of Rats. Am. J. Biomed. Life Sci. 2014, 2(6-1), 1-4. doi: 10.11648/j.ajbls.s.2014020601.11

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AMA Style

Vadim Vyacheslavovich Davydov, Anatoliy Ivanovich Bozhkov, Evgeniya Romanovna Grabovetskaya. Age-Dependent Change in Aldo-Keto Reductases Composition in the Blood of Rats. Am J Biomed Life Sci. 2014;2(6-1):1-4. doi: 10.11648/j.ajbls.s.2014020601.11

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@article{10.11648/j.ajbls.s.2014020601.11,
  author = {Vadim Vyacheslavovich Davydov and Anatoliy Ivanovich Bozhkov and Evgeniya Romanovna Grabovetskaya},
  title = {Age-Dependent Change in Aldo-Keto Reductases Composition in the Blood of Rats},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {2},
  number = {6-1},
  pages = {1-4},
  doi = {10.11648/j.ajbls.s.2014020601.11},
  url = {https://doi.org/10.11648/j.ajbls.s.2014020601.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.s.2014020601.11},
  abstract = {Resistance of the organism to the stress injury changes during ontogenesis. In this regard, the incidence of cardiovascular, central nervous, endocrine systems, etc. increases at certain stages of individual development. Taking into account the fact that the development of stress-caused lesions is associated with accumulation of carbonyl products of free radical oxidation in cells, we have suggested that the one of the reasons for this phenomenon is age-related changes in the efficiency of the scavenging of endogenous aldehydes in the organism. In view of this fact, spectrum of aldo-keto reductases in blood serum of rats at different stages of ontogenesis was investigated by means of electrophoresis. Identical changes in the composition of aldo-keto reductases spectrum of blood in early immature age and in aging have been shown. Change in aldo-keto reductases spectrum modulates the role of reductive pathway of endogenous aldehydes scavenging in the organism. Thus, in child age and aging efficiency of scavenging of carbonyl products of free radical oxidation in cells is limited and especially when they are intensively produced. This results in increase of the susceptibility of the organism to oxidative stress.},
 year = {2014}
}

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TY  - JOUR
T1  - Age-Dependent Change in Aldo-Keto Reductases Composition in the Blood of Rats
AU  - Vadim Vyacheslavovich Davydov
AU  - Anatoliy Ivanovich Bozhkov
AU  - Evgeniya Romanovna Grabovetskaya
Y1  - 2014/08/13
PY  - 2014
N1  - https://doi.org/10.11648/j.ajbls.s.2014020601.11
DO  - 10.11648/j.ajbls.s.2014020601.11
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 1
EP  - 4
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.s.2014020601.11
AB  - Resistance of the organism to the stress injury changes during ontogenesis. In this regard, the incidence of cardiovascular, central nervous, endocrine systems, etc. increases at certain stages of individual development. Taking into account the fact that the development of stress-caused lesions is associated with accumulation of carbonyl products of free radical oxidation in cells, we have suggested that the one of the reasons for this phenomenon is age-related changes in the efficiency of the scavenging of endogenous aldehydes in the organism. In view of this fact, spectrum of aldo-keto reductases in blood serum of rats at different stages of ontogenesis was investigated by means of electrophoresis. Identical changes in the composition of aldo-keto reductases spectrum of blood in early immature age and in aging have been shown. Change in aldo-keto reductases spectrum modulates the role of reductive pathway of endogenous aldehydes scavenging in the organism. Thus, in child age and aging efficiency of scavenging of carbonyl products of free radical oxidation in cells is limited and especially when they are intensively produced. This results in increase of the susceptibility of the organism to oxidative stress.
VL  - 2
IS  - 6-1
ER  -

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