Objective: This study aims to assess the diagnostic utility of ultrasonography and which methods of measuring attenuation on computed tomography scans is best for detection and grading of hepatic fat content in patients with chronic hepatitis C virus (HCV) infection. Materials and Methods: This study included 65 patients, withchronic hepatitis C virus infection, who had liver biopsies as a part of pre-requirement for interferon therapy. All patients submitted to ultrasound; non enhanced and enhanced CT. Attenuation measurements were obtained from 3 regions of interest in the liver and three in the spleen on both unenhanced and portal phase contrast-enhanced CT images. Hepatic attenuation measurements were analyzed both with and without normalization with the spleen. Normalization included both differences and ratios between hepatic and splenic attenuation values. Average attenuation values of the liver were compared with pathologic fat content, as were the differences and ratios between hepatic and splenic attenuation values. Results: Ultrasound had a sensitivity of 76% and specificity 73.3% in the diagnosis of hepatic steatosis. Also ultrasound accurately graded 41 out of the 65 (63.1%) patients included in the study. The simple measurement of hepatic attenuation on non enhanced CT (CTL) had the best parameters for diagnosis of hepatic steatosis with sensitivity 83%, specificity 93.3% and positive predictive value (PPV) 97.6%. All series of R2 values for the unenhanced CT scans were higher than those for the contrast-enhanced images. The R2 values for simple liver attenuation measurement without comparison with splenic attenuation were higher than the values in which splenic measurements were considered. Conclusion: Ultrasound and non enhanced CT can be used as screening tools for detection of hepatic steatosis in patients with chronic hepatitis C virus patients. Simple measurement of hepatic attenuation on unenhanced CT is more accurate than differential liver spleen values. Also, unenhanced CT can differentiate between mild-moderate and severe steatosis.
| Published in | International Journal of Medical Imaging (Volume 2, Issue 5) |
| DOI | 10.11648/j.ijmi.20140205.14 |
| Page(s) | 112-118 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2014. Published by Science Publishing Group |
Hepatic Steatosis, CT, Ultrasound, Hepatitis C Viral Infection
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APA Style
Manal Ezzat Badawy, Mohamed Fouad Sherif, Elsayed Tharwa. (2014). Accuracy of Ultrasonography and Different CT Techniques in Diagnosis and Grading of Hepatic Steatosis in Chronic Hepatitis C Virus Patients. International Journal of Medical Imaging, 2(5), 112-118. https://doi.org/10.11648/j.ijmi.20140205.14
ACS Style
Manal Ezzat Badawy; Mohamed Fouad Sherif; Elsayed Tharwa. Accuracy of Ultrasonography and Different CT Techniques in Diagnosis and Grading of Hepatic Steatosis in Chronic Hepatitis C Virus Patients. Int. J. Med. Imaging 2014, 2(5), 112-118. doi: 10.11648/j.ijmi.20140205.14
AMA Style
Manal Ezzat Badawy, Mohamed Fouad Sherif, Elsayed Tharwa. Accuracy of Ultrasonography and Different CT Techniques in Diagnosis and Grading of Hepatic Steatosis in Chronic Hepatitis C Virus Patients. Int J Med Imaging. 2014;2(5):112-118. doi: 10.11648/j.ijmi.20140205.14
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Download@article{10.11648/j.ijmi.20140205.14,
author = {Manal Ezzat Badawy and Mohamed Fouad Sherif and Elsayed Tharwa},
title = {Accuracy of Ultrasonography and Different CT Techniques in Diagnosis and Grading of Hepatic Steatosis in Chronic Hepatitis C Virus Patients},
journal = {International Journal of Medical Imaging},
volume = {2},
number = {5},
pages = {112-118},
doi = {10.11648/j.ijmi.20140205.14},
url = {https://doi.org/10.11648/j.ijmi.20140205.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmi.20140205.14},
abstract = {Objective: This study aims to assess the diagnostic utility of ultrasonography and which methods of measuring attenuation on computed tomography scans is best for detection and grading of hepatic fat content in patients with chronic hepatitis C virus (HCV) infection. Materials and Methods: This study included 65 patients, withchronic hepatitis C virus infection, who had liver biopsies as a part of pre-requirement for interferon therapy. All patients submitted to ultrasound; non enhanced and enhanced CT. Attenuation measurements were obtained from 3 regions of interest in the liver and three in the spleen on both unenhanced and portal phase contrast-enhanced CT images. Hepatic attenuation measurements were analyzed both with and without normalization with the spleen. Normalization included both differences and ratios between hepatic and splenic attenuation values. Average attenuation values of the liver were compared with pathologic fat content, as were the differences and ratios between hepatic and splenic attenuation values. Results: Ultrasound had a sensitivity of 76% and specificity 73.3% in the diagnosis of hepatic steatosis. Also ultrasound accurately graded 41 out of the 65 (63.1%) patients included in the study. The simple measurement of hepatic attenuation on non enhanced CT (CTL) had the best parameters for diagnosis of hepatic steatosis with sensitivity 83%, specificity 93.3% and positive predictive value (PPV) 97.6%. All series of R2 values for the unenhanced CT scans were higher than those for the contrast-enhanced images. The R2 values for simple liver attenuation measurement without comparison with splenic attenuation were higher than the values in which splenic measurements were considered. Conclusion: Ultrasound and non enhanced CT can be used as screening tools for detection of hepatic steatosis in patients with chronic hepatitis C virus patients. Simple measurement of hepatic attenuation on unenhanced CT is more accurate than differential liver spleen values. Also, unenhanced CT can differentiate between mild-moderate and severe steatosis.},
year = {2014}
}
TY - JOUR T1 - Accuracy of Ultrasonography and Different CT Techniques in Diagnosis and Grading of Hepatic Steatosis in Chronic Hepatitis C Virus Patients AU - Manal Ezzat Badawy AU - Mohamed Fouad Sherif AU - Elsayed Tharwa Y1 - 2014/09/30 PY - 2014 N1 - https://doi.org/10.11648/j.ijmi.20140205.14 DO - 10.11648/j.ijmi.20140205.14 T2 - International Journal of Medical Imaging JF - International Journal of Medical Imaging JO - International Journal of Medical Imaging SP - 112 EP - 118 PB - Science Publishing Group SN - 2330-832X UR - https://doi.org/10.11648/j.ijmi.20140205.14 AB - Objective: This study aims to assess the diagnostic utility of ultrasonography and which methods of measuring attenuation on computed tomography scans is best for detection and grading of hepatic fat content in patients with chronic hepatitis C virus (HCV) infection. Materials and Methods: This study included 65 patients, withchronic hepatitis C virus infection, who had liver biopsies as a part of pre-requirement for interferon therapy. All patients submitted to ultrasound; non enhanced and enhanced CT. Attenuation measurements were obtained from 3 regions of interest in the liver and three in the spleen on both unenhanced and portal phase contrast-enhanced CT images. Hepatic attenuation measurements were analyzed both with and without normalization with the spleen. Normalization included both differences and ratios between hepatic and splenic attenuation values. Average attenuation values of the liver were compared with pathologic fat content, as were the differences and ratios between hepatic and splenic attenuation values. Results: Ultrasound had a sensitivity of 76% and specificity 73.3% in the diagnosis of hepatic steatosis. Also ultrasound accurately graded 41 out of the 65 (63.1%) patients included in the study. The simple measurement of hepatic attenuation on non enhanced CT (CTL) had the best parameters for diagnosis of hepatic steatosis with sensitivity 83%, specificity 93.3% and positive predictive value (PPV) 97.6%. All series of R2 values for the unenhanced CT scans were higher than those for the contrast-enhanced images. The R2 values for simple liver attenuation measurement without comparison with splenic attenuation were higher than the values in which splenic measurements were considered. Conclusion: Ultrasound and non enhanced CT can be used as screening tools for detection of hepatic steatosis in patients with chronic hepatitis C virus patients. Simple measurement of hepatic attenuation on unenhanced CT is more accurate than differential liver spleen values. Also, unenhanced CT can differentiate between mild-moderate and severe steatosis. VL - 2 IS - 5 ER -
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