The range of T cell abnormalities in advanced HIV-1 infection treatment is broad. The defects are both quantitative and qualitative and affect virtually every limb of the immune system. Beyond the precise measurement of naive T cells (CD45RA+CCR7+CD27+CD28+), the differential expression of different molecules on T cell allows the distinction between numerous subsets of resting or antigen-experienced T cells on the treatment. However, in spite of intense investigation, the mechanisms underlying highly active antiretroviral therapy (HAART) –induce immune reconstitution remain to be fully characterized. HAART treatment induced changes in the peripheral distribution of naïve (CD45RA+ CD62L+) and memory CD45RA- CD62L+) cells, CCR5, CXCR4-, CD95- expressing T cells, T-reg cells and on gamma delta (ϒδ) T cells. As a concluding remark prolonged suppression of plasma viral load ( pVL) by HAART improves not only ɑβ T-cell function but also ϒδ T-cell reactivity, and it is strongly recommended that once started the treatment, sever immunocompromized patient should continue the treatment for long time.
| Published in | International Journal of Immunology (Volume 3, Issue 6) |
| DOI | 10.11648/j.iji.20150306.11 |
| Page(s) | 57-71 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2015. Published by Science Publishing Group |
T-lymphocytes, HIV-1 Infection, Highly Active Antiretroviral Therapy
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APA Style
Addisu Gize Yeshanew, Afework Kassu Gizaw, Biniam Mathewos Tebeje. (2015). Effect of Highly Active Antiretroviral Therapy on T-Cell Sub-population Profile in Human Immunodeficiency Virus-1 Infected Patients. International Journal of Immunology, 3(6), 57-71. https://doi.org/10.11648/j.iji.20150306.11
ACS Style
Addisu Gize Yeshanew; Afework Kassu Gizaw; Biniam Mathewos Tebeje. Effect of Highly Active Antiretroviral Therapy on T-Cell Sub-population Profile in Human Immunodeficiency Virus-1 Infected Patients. Int. J. Immunol. 2015, 3(6), 57-71. doi: 10.11648/j.iji.20150306.11
AMA Style
Addisu Gize Yeshanew, Afework Kassu Gizaw, Biniam Mathewos Tebeje. Effect of Highly Active Antiretroviral Therapy on T-Cell Sub-population Profile in Human Immunodeficiency Virus-1 Infected Patients. Int J Immunol. 2015;3(6):57-71. doi: 10.11648/j.iji.20150306.11
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Download@article{10.11648/j.iji.20150306.11,
author = {Addisu Gize Yeshanew and Afework Kassu Gizaw and Biniam Mathewos Tebeje},
title = {Effect of Highly Active Antiretroviral Therapy on T-Cell Sub-population Profile in Human Immunodeficiency Virus-1 Infected Patients},
journal = {International Journal of Immunology},
volume = {3},
number = {6},
pages = {57-71},
doi = {10.11648/j.iji.20150306.11},
url = {https://doi.org/10.11648/j.iji.20150306.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.iji.20150306.11},
abstract = {The range of T cell abnormalities in advanced HIV-1 infection treatment is broad. The defects are both quantitative and qualitative and affect virtually every limb of the immune system. Beyond the precise measurement of naive T cells (CD45RA+CCR7+CD27+CD28+), the differential expression of different molecules on T cell allows the distinction between numerous subsets of resting or antigen-experienced T cells on the treatment. However, in spite of intense investigation, the mechanisms underlying highly active antiretroviral therapy (HAART) –induce immune reconstitution remain to be fully characterized. HAART treatment induced changes in the peripheral distribution of naïve (CD45RA+ CD62L+) and memory CD45RA- CD62L+) cells, CCR5, CXCR4-, CD95- expressing T cells, T-reg cells and on gamma delta (ϒδ) T cells. As a concluding remark prolonged suppression of plasma viral load ( pVL) by HAART improves not only ɑβ T-cell function but also ϒδ T-cell reactivity, and it is strongly recommended that once started the treatment, sever immunocompromized patient should continue the treatment for long time.},
year = {2015}
}
TY - JOUR T1 - Effect of Highly Active Antiretroviral Therapy on T-Cell Sub-population Profile in Human Immunodeficiency Virus-1 Infected Patients AU - Addisu Gize Yeshanew AU - Afework Kassu Gizaw AU - Biniam Mathewos Tebeje Y1 - 2015/11/26 PY - 2015 N1 - https://doi.org/10.11648/j.iji.20150306.11 DO - 10.11648/j.iji.20150306.11 T2 - International Journal of Immunology JF - International Journal of Immunology JO - International Journal of Immunology SP - 57 EP - 71 PB - Science Publishing Group SN - 2329-1753 UR - https://doi.org/10.11648/j.iji.20150306.11 AB - The range of T cell abnormalities in advanced HIV-1 infection treatment is broad. The defects are both quantitative and qualitative and affect virtually every limb of the immune system. Beyond the precise measurement of naive T cells (CD45RA+CCR7+CD27+CD28+), the differential expression of different molecules on T cell allows the distinction between numerous subsets of resting or antigen-experienced T cells on the treatment. However, in spite of intense investigation, the mechanisms underlying highly active antiretroviral therapy (HAART) –induce immune reconstitution remain to be fully characterized. HAART treatment induced changes in the peripheral distribution of naïve (CD45RA+ CD62L+) and memory CD45RA- CD62L+) cells, CCR5, CXCR4-, CD95- expressing T cells, T-reg cells and on gamma delta (ϒδ) T cells. As a concluding remark prolonged suppression of plasma viral load ( pVL) by HAART improves not only ɑβ T-cell function but also ϒδ T-cell reactivity, and it is strongly recommended that once started the treatment, sever immunocompromized patient should continue the treatment for long time. VL - 3 IS - 6 ER -
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