Empirical Studies about Inhibiting Proliferation of Zedoary Turmeric oil, Cinobufacini and Solanine on Gastric Carcinoma Cells

Xuejun Zhan; Daze Xie; Yingyin Hu; Ge Dai; Yanping Xu

doi:doi:10.11648/j.crj.20140203.11

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Empirical Studies about Inhibiting Proliferation of Zedoary Turmeric oil, Cinobufacini and Solanine on Gastric Carcinoma Cells

Xuejun Zhan, Daze Xie, Yingyin Hu, Ge Dai, Yanping Xu

Published in Cancer Research Journal (Volume 2, Issue 3)

Received: 17 April 2014 Accepted: 23 May 2014 Published: 10 June 2014

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Abstract

Purpose: To investigate the anti-proliferative effects of anti-cancer Chinese medicinal materials such as zedoary turmeric oil, cinobufacini and solanine on gastric carcinoma cell line NKM45. Methods: Bioluminescence assay (BLA) was applied to determine the ATP concentration when NKM45 was exposed to the three Chinese medicinal materials. The influence of zedoary turmeric oil on the growth curve of NKM45 cells was also analyzed. And the concentration of ATP was compared with NKM45 cells that were exposed to 5-Fluorouracil(5-Fu). Results: The concentration of ATP was significantly decreased when the NKM45 cells were exposed to the three Chinese medicinal materials and 5-Fu (P<0.05~P<0.01). There was no significant difference in the ATP concentration between MKM45 cells that were treated with the three Chinese medicinal materials and those exposed to 5-Fu (P>0.05). The zedoary turmeric oil significantly inhibited the survival rate of NKM45 cells. Conclusions: Zedoary turmeric oil, cinobufacin, and solanine can inhibit the proliferative activity of NKM45 cells. They have exploitation potential with broad market prospect.

Published in	Cancer Research Journal (Volume 2, Issue 3)
DOI	10.11648/j.crj.20140203.11
Page(s)	42-46
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Gastric Carcinoma Cells, Anti- Cancer Chinese Medicinal Materials, ATP Concentration

References

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APA Style

Xuejun Zhan, Daze Xie, Yingyin Hu, Ge Dai, Yanping Xu. (2014). Empirical Studies about Inhibiting Proliferation of Zedoary Turmeric oil, Cinobufacini and Solanine on Gastric Carcinoma Cells. Cancer Research Journal, 2(3), 42-46. https://doi.org/10.11648/j.crj.20140203.11

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ACS Style

Xuejun Zhan; Daze Xie; Yingyin Hu; Ge Dai; Yanping Xu. Empirical Studies about Inhibiting Proliferation of Zedoary Turmeric oil, Cinobufacini and Solanine on Gastric Carcinoma Cells. Cancer Res. J. 2014, 2(3), 42-46. doi: 10.11648/j.crj.20140203.11

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AMA Style

Xuejun Zhan, Daze Xie, Yingyin Hu, Ge Dai, Yanping Xu. Empirical Studies about Inhibiting Proliferation of Zedoary Turmeric oil, Cinobufacini and Solanine on Gastric Carcinoma Cells. Cancer Res J. 2014;2(3):42-46. doi: 10.11648/j.crj.20140203.11

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@article{10.11648/j.crj.20140203.11,
  author = {Xuejun Zhan and Daze Xie and Yingyin Hu and Ge Dai and Yanping Xu},
  title = {Empirical Studies about Inhibiting Proliferation of Zedoary Turmeric oil, Cinobufacini and Solanine on Gastric Carcinoma Cells},
  journal = {Cancer Research Journal},
  volume = {2},
  number = {3},
  pages = {42-46},
  doi = {10.11648/j.crj.20140203.11},
  url = {https://doi.org/10.11648/j.crj.20140203.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20140203.11},
  abstract = {Purpose: To investigate the anti-proliferative effects of anti-cancer Chinese medicinal materials such as zedoary turmeric oil, cinobufacini and solanine on gastric carcinoma cell line NKM45. Methods: Bioluminescence assay (BLA) was applied to determine the ATP concentration when NKM45 was exposed to the three Chinese medicinal materials. The influence of zedoary turmeric oil on the growth curve of NKM45 cells was also analyzed. And the concentration of ATP was compared with NKM45 cells that were exposed to 5-Fluorouracil(5-Fu). Results: The concentration of ATP was significantly decreased when the NKM45 cells were exposed to the three Chinese medicinal materials and 5-Fu (P0.05). The zedoary turmeric oil significantly inhibited the survival rate of NKM45 cells. Conclusions: Zedoary turmeric oil, cinobufacin, and solanine can inhibit the proliferative activity of NKM45 cells. They have exploitation potential with broad market prospect.},
 year = {2014}
}

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TY - JOUR
T1 - Empirical Studies about Inhibiting Proliferation of Zedoary Turmeric oil, Cinobufacini and Solanine on Gastric Carcinoma Cells
AU - Xuejun Zhan
AU - Daze Xie
AU - Yingyin Hu
AU - Ge Dai
AU - Yanping Xu
Y1 - 2014/06/10
PY - 2014
N1 - https://doi.org/10.11648/j.crj.20140203.11
DO - 10.11648/j.crj.20140203.11
T2 - Cancer Research Journal
JF - Cancer Research Journal
JO - Cancer Research Journal
SP - 42
EP - 46
PB - Science Publishing Group
SN - 2330-8214
UR - https://doi.org/10.11648/j.crj.20140203.11
AB - Purpose: To investigate the anti-proliferative effects of anti-cancer Chinese medicinal materials such as zedoary turmeric oil, cinobufacini and solanine on gastric carcinoma cell line NKM45. Methods: Bioluminescence assay (BLA) was applied to determine the ATP concentration when NKM45 was exposed to the three Chinese medicinal materials. The influence of zedoary turmeric oil on the growth curve of NKM45 cells was also analyzed. And the concentration of ATP was compared with NKM45 cells that were exposed to 5-Fluorouracil(5-Fu). Results: The concentration of ATP was significantly decreased when the NKM45 cells were exposed to the three Chinese medicinal materials and 5-Fu (P0.05). The zedoary turmeric oil significantly inhibited the survival rate of NKM45 cells. Conclusions: Zedoary turmeric oil, cinobufacin, and solanine can inhibit the proliferative activity of NKM45 cells. They have exploitation potential with broad market prospect.
VL - 2
IS - 3
ER -

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Author Information

Xuejun Zhan

Department of Detection Center, Key Laboratory of Biological Medical of Jiangxi, Jiangxi Academy of Medical Science, Jiangxi, Nanchang, China
Daze Xie

Department of Detection Center, Key Laboratory of Biological Medical of Jiangxi, Jiangxi Academy of Medical Science, Jiangxi, Nanchang, China
Yingyin Hu

Cancer Research Laboratory, Key Laboratory of Biological Medical of Jiangxi, Jiangxi Academy of Medical Science, Jiangxi, Nanchang, China
Ge Dai

Department of Nuclear Medicine, Jiangxi Academy of Medical Science, Jiangxi, Nanchang, China
Yanping Xu

Department of Detection Center, Key Laboratory of Biological Medical of Jiangxi, Jiangxi Academy of Medical Science, Jiangxi, Nanchang, China

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APA Style

Xuejun Zhan, Daze Xie, Yingyin Hu, Ge Dai, Yanping Xu. (2014). Empirical Studies about Inhibiting Proliferation of Zedoary Turmeric oil, Cinobufacini and Solanine on Gastric Carcinoma Cells. Cancer Research Journal, 2(3), 42-46. https://doi.org/10.11648/j.crj.20140203.11

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ACS Style

Xuejun Zhan; Daze Xie; Yingyin Hu; Ge Dai; Yanping Xu. Empirical Studies about Inhibiting Proliferation of Zedoary Turmeric oil, Cinobufacini and Solanine on Gastric Carcinoma Cells. Cancer Res. J. 2014, 2(3), 42-46. doi: 10.11648/j.crj.20140203.11

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AMA Style

Xuejun Zhan, Daze Xie, Yingyin Hu, Ge Dai, Yanping Xu. Empirical Studies about Inhibiting Proliferation of Zedoary Turmeric oil, Cinobufacini and Solanine on Gastric Carcinoma Cells. Cancer Res J. 2014;2(3):42-46. doi: 10.11648/j.crj.20140203.11

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@article{10.11648/j.crj.20140203.11,
  author = {Xuejun Zhan and Daze Xie and Yingyin Hu and Ge Dai and Yanping Xu},
  title = {Empirical Studies about Inhibiting Proliferation of Zedoary Turmeric oil, Cinobufacini and Solanine on Gastric Carcinoma Cells},
  journal = {Cancer Research Journal},
  volume = {2},
  number = {3},
  pages = {42-46},
  doi = {10.11648/j.crj.20140203.11},
  url = {https://doi.org/10.11648/j.crj.20140203.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20140203.11},
  abstract = {Purpose: To investigate the anti-proliferative effects of anti-cancer Chinese medicinal materials such as zedoary turmeric oil, cinobufacini and solanine on gastric carcinoma cell line NKM45. Methods: Bioluminescence assay (BLA) was applied to determine the ATP concentration when NKM45 was exposed to the three Chinese medicinal materials. The influence of zedoary turmeric oil on the growth curve of NKM45 cells was also analyzed. And the concentration of ATP was compared with NKM45 cells that were exposed to 5-Fluorouracil(5-Fu). Results: The concentration of ATP was significantly decreased when the NKM45 cells were exposed to the three Chinese medicinal materials and 5-Fu (P0.05). The zedoary turmeric oil significantly inhibited the survival rate of NKM45 cells. Conclusions: Zedoary turmeric oil, cinobufacin, and solanine can inhibit the proliferative activity of NKM45 cells. They have exploitation potential with broad market prospect.},
 year = {2014}
}

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