Major depression is a common form of mental disorder affecting approximately 15% of the population at least once during lifetime. The etiology of depression is complex with potential contributions from central and peripheral systemic factors, and several CNS impacting diseases. Presently employed antidepressant medications are poorly responded to by upwards of 50% of patients and typically require weeks of treatment to be effective. Recent post-mortem brain scans indicate significant volume reductions in two limbic brain structures, the hippocampus and prefrontal cortex of depressed patients. These findings focus attention on hippocampal plasticity in the neuropathology of depression and the possible dysfunction of several important processes including neurogenesis, synaptogenesis, and contributions by neurotrophic growth factors. The hepatocyte growth factor (HGF)/c-Met receptor system is a powerful mediator of synaptogenesis and neurogenesis, and if adequately activated may serve to counter the neuropathology of depression. The brain renin-angiotensin system (RAS) interacts with the HGF/c-Met system and plays a major role in responding to stress and the pathophysiology of depression. We have developed an angiotensin IV-based small molecule designed to activate the HGF/c-Met receptor system in order to provide neuroprotection, synaptogenesis, and neurogenesis in the hippocampus and prefrontal cortex. This analog may be efficacious in treating the neuropathology of depression.
| Published in | American Journal of Psychiatry and Neuroscience (Volume 3, Issue 5) |
| DOI | 10.11648/j.ajpn.20150305.11 |
| Page(s) | 77-89 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2015. Published by Science Publishing Group |
Depression, Angiotensin II, Angiotensin IV, AT4 Receptor, Hepatocyte Growth Factor, C-Met Receptor, Dihexa
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APA Style
John W. Wright, Joseph W. Harding. (2015). The Development of Small Molecule Angiotensin IV-Based Analogs to Treat Depression. American Journal of Psychiatry and Neuroscience, 3(5), 77-89. https://doi.org/10.11648/j.ajpn.20150305.11
ACS Style
John W. Wright; Joseph W. Harding. The Development of Small Molecule Angiotensin IV-Based Analogs to Treat Depression. Am. J. Psychiatry Neurosci. 2015, 3(5), 77-89. doi: 10.11648/j.ajpn.20150305.11
AMA Style
John W. Wright, Joseph W. Harding. The Development of Small Molecule Angiotensin IV-Based Analogs to Treat Depression. Am J Psychiatry Neurosci. 2015;3(5):77-89. doi: 10.11648/j.ajpn.20150305.11
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Download@article{10.11648/j.ajpn.20150305.11,
author = {John W. Wright and Joseph W. Harding},
title = {The Development of Small Molecule Angiotensin IV-Based Analogs to Treat Depression},
journal = {American Journal of Psychiatry and Neuroscience},
volume = {3},
number = {5},
pages = {77-89},
doi = {10.11648/j.ajpn.20150305.11},
url = {https://doi.org/10.11648/j.ajpn.20150305.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpn.20150305.11},
abstract = {Major depression is a common form of mental disorder affecting approximately 15% of the population at least once during lifetime. The etiology of depression is complex with potential contributions from central and peripheral systemic factors, and several CNS impacting diseases. Presently employed antidepressant medications are poorly responded to by upwards of 50% of patients and typically require weeks of treatment to be effective. Recent post-mortem brain scans indicate significant volume reductions in two limbic brain structures, the hippocampus and prefrontal cortex of depressed patients. These findings focus attention on hippocampal plasticity in the neuropathology of depression and the possible dysfunction of several important processes including neurogenesis, synaptogenesis, and contributions by neurotrophic growth factors. The hepatocyte growth factor (HGF)/c-Met receptor system is a powerful mediator of synaptogenesis and neurogenesis, and if adequately activated may serve to counter the neuropathology of depression. The brain renin-angiotensin system (RAS) interacts with the HGF/c-Met system and plays a major role in responding to stress and the pathophysiology of depression. We have developed an angiotensin IV-based small molecule designed to activate the HGF/c-Met receptor system in order to provide neuroprotection, synaptogenesis, and neurogenesis in the hippocampus and prefrontal cortex. This analog may be efficacious in treating the neuropathology of depression.},
year = {2015}
}
TY - JOUR T1 - The Development of Small Molecule Angiotensin IV-Based Analogs to Treat Depression AU - John W. Wright AU - Joseph W. Harding Y1 - 2015/08/03 PY - 2015 N1 - https://doi.org/10.11648/j.ajpn.20150305.11 DO - 10.11648/j.ajpn.20150305.11 T2 - American Journal of Psychiatry and Neuroscience JF - American Journal of Psychiatry and Neuroscience JO - American Journal of Psychiatry and Neuroscience SP - 77 EP - 89 PB - Science Publishing Group SN - 2330-426X UR - https://doi.org/10.11648/j.ajpn.20150305.11 AB - Major depression is a common form of mental disorder affecting approximately 15% of the population at least once during lifetime. The etiology of depression is complex with potential contributions from central and peripheral systemic factors, and several CNS impacting diseases. Presently employed antidepressant medications are poorly responded to by upwards of 50% of patients and typically require weeks of treatment to be effective. Recent post-mortem brain scans indicate significant volume reductions in two limbic brain structures, the hippocampus and prefrontal cortex of depressed patients. These findings focus attention on hippocampal plasticity in the neuropathology of depression and the possible dysfunction of several important processes including neurogenesis, synaptogenesis, and contributions by neurotrophic growth factors. The hepatocyte growth factor (HGF)/c-Met receptor system is a powerful mediator of synaptogenesis and neurogenesis, and if adequately activated may serve to counter the neuropathology of depression. The brain renin-angiotensin system (RAS) interacts with the HGF/c-Met system and plays a major role in responding to stress and the pathophysiology of depression. We have developed an angiotensin IV-based small molecule designed to activate the HGF/c-Met receptor system in order to provide neuroprotection, synaptogenesis, and neurogenesis in the hippocampus and prefrontal cortex. This analog may be efficacious in treating the neuropathology of depression. VL - 3 IS - 5 ER -
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