Methanolic flower extracts of Plumeria alba and P. rubra were tested for in vitro antioxidant potential, cytotoxicity and hypolipidemic activities. DPPH assay of methanolic extract of Plumeria revealed that 81% and 72% inhibition by P. alba and P. rubra respectively and the total phenolic content was found as 173.9 µg ml-1 and 167.3 µg ml-1. Significant free radical scavenging activities of 1.74 mg ml-1and 1.67 mg ml-1 were observed due to the higher phenolic content. Anti-chlolesterol assay of the extracts demonstrated P. rubra has highest hypolipidemic activity (60%) followed by P. alba (52%). MTT assay using HCT 116 cell lines revealed the antiproliferative and cytotoxic activities of P. alba with an IC50 value of 259.9 µg ml-1. Plumeria species could be a new source of drugs for the treatment of colon cancer and hyperlipidemic conditions due to higher antioxidant potential and phenolic content which was revealed from the study.
| Published in |
American Journal of Life Sciences (Volume 2, Issue 6-1)
This article belongs to the Special Issue Recent Developments in Health Care through Plants and Microbes |
| DOI | 10.11648/j.ajls.s.2014020601.13 |
| Page(s) | 11-15 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2014. Published by Science Publishing Group |
Plumeria, Antioxidant, Anticancer, Anti-Cholesterol, Colon Cancer
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APA Style
Hafizur Rahman, Vijaya Badra Reddy, Soumya Ghosh, Sandeep Kumar Mistry, Geetika Pant, et al. (2014). Antioxidant, Cytotoxic and Hypolipidemic Activities of Plumeria alba L. and Plumeria rubra L.. American Journal of Life Sciences, 2(6-1), 11-15. https://doi.org/10.11648/j.ajls.s.2014020601.13
ACS Style
Hafizur Rahman; Vijaya Badra Reddy; Soumya Ghosh; Sandeep Kumar Mistry; Geetika Pant, et al. Antioxidant, Cytotoxic and Hypolipidemic Activities of Plumeria alba L. and Plumeria rubra L.. Am. J. Life Sci. 2014, 2(6-1), 11-15. doi: 10.11648/j.ajls.s.2014020601.13
AMA Style
Hafizur Rahman, Vijaya Badra Reddy, Soumya Ghosh, Sandeep Kumar Mistry, Geetika Pant, et al. Antioxidant, Cytotoxic and Hypolipidemic Activities of Plumeria alba L. and Plumeria rubra L.. Am J Life Sci. 2014;2(6-1):11-15. doi: 10.11648/j.ajls.s.2014020601.13
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Download@article{10.11648/j.ajls.s.2014020601.13,
author = {Hafizur Rahman and Vijaya Badra Reddy and Soumya Ghosh and Sandeep Kumar Mistry and Geetika Pant and Sibi G.},
title = {Antioxidant, Cytotoxic and Hypolipidemic Activities of Plumeria alba L. and Plumeria rubra L.},
journal = {American Journal of Life Sciences},
volume = {2},
number = {6-1},
pages = {11-15},
doi = {10.11648/j.ajls.s.2014020601.13},
url = {https://doi.org/10.11648/j.ajls.s.2014020601.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.s.2014020601.13},
abstract = {Methanolic flower extracts of Plumeria alba and P. rubra were tested for in vitro antioxidant potential, cytotoxicity and hypolipidemic activities. DPPH assay of methanolic extract of Plumeria revealed that 81% and 72% inhibition by P. alba and P. rubra respectively and the total phenolic content was found as 173.9 µg ml-1 and 167.3 µg ml-1. Significant free radical scavenging activities of 1.74 mg ml-1and 1.67 mg ml-1 were observed due to the higher phenolic content. Anti-chlolesterol assay of the extracts demonstrated P. rubra has highest hypolipidemic activity (60%) followed by P. alba (52%). MTT assay using HCT 116 cell lines revealed the antiproliferative and cytotoxic activities of P. alba with an IC50 value of 259.9 µg ml-1. Plumeria species could be a new source of drugs for the treatment of colon cancer and hyperlipidemic conditions due to higher antioxidant potential and phenolic content which was revealed from the study.},
year = {2014}
}
TY - JOUR T1 - Antioxidant, Cytotoxic and Hypolipidemic Activities of Plumeria alba L. and Plumeria rubra L. AU - Hafizur Rahman AU - Vijaya Badra Reddy AU - Soumya Ghosh AU - Sandeep Kumar Mistry AU - Geetika Pant AU - Sibi G. Y1 - 2014/09/17 PY - 2014 N1 - https://doi.org/10.11648/j.ajls.s.2014020601.13 DO - 10.11648/j.ajls.s.2014020601.13 T2 - American Journal of Life Sciences JF - American Journal of Life Sciences JO - American Journal of Life Sciences SP - 11 EP - 15 PB - Science Publishing Group SN - 2328-5737 UR - https://doi.org/10.11648/j.ajls.s.2014020601.13 AB - Methanolic flower extracts of Plumeria alba and P. rubra were tested for in vitro antioxidant potential, cytotoxicity and hypolipidemic activities. DPPH assay of methanolic extract of Plumeria revealed that 81% and 72% inhibition by P. alba and P. rubra respectively and the total phenolic content was found as 173.9 µg ml-1 and 167.3 µg ml-1. Significant free radical scavenging activities of 1.74 mg ml-1and 1.67 mg ml-1 were observed due to the higher phenolic content. Anti-chlolesterol assay of the extracts demonstrated P. rubra has highest hypolipidemic activity (60%) followed by P. alba (52%). MTT assay using HCT 116 cell lines revealed the antiproliferative and cytotoxic activities of P. alba with an IC50 value of 259.9 µg ml-1. Plumeria species could be a new source of drugs for the treatment of colon cancer and hyperlipidemic conditions due to higher antioxidant potential and phenolic content which was revealed from the study. VL - 2 IS - 6-1 ER -
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