Study of Serum Osteoprotegerin Level in Uremic Patients and Its Relation to Renal Bone Disease

Mohamed Magdy; Mona Mostafa; Heba Elshair; Hesham Elghoneimy

doi:doi:10.11648/j.ajim.s.2016040201.12

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Study of Serum Osteoprotegerin Level in Uremic Patients and Its Relation to Renal Bone Disease

Mohamed Magdy, Mona Mostafa, Heba Elshair, Hesham Elghoneimy

Published in American Journal of Internal Medicine (Volume 4, Issue 2-1)

Received: 11 September 2015 Accepted: 13 September 2015 Published: 25 October 2015

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Abstract

Introduction: Bone disease associated with renal failure is termed renal osteodystrophy and is quite heterogeneous. Microscopic examination of a bone biopsy specimen is still considered the gold standard for diagnosis. Nevertheless, recent studies suggest that serum markers of bone formation and resorption may be of additional help in assessing bone turnover. Osteoprotegerin (OPG) and osteoprotegerin ligand (OPGL) constitute a complex mediator system involved in the regulation of the resorption process in bone. The present work aimed at studying the serum levels of osteoprotegerin and relation of osteoprotegerin to PTH and x-ray features of renal osteodystrophy has been studied. Subjects and methods: The present study was conducted on three groups Group I: 20 patients with chronic kidney disease( CKD) divided into two subgroups: Group Ia: 10 patients in stage 2 CKD (GFR of 60-89 ml/min) and stage 3 CKD (GFR of 30-59 ml/min).Group Ib: 10 patients in stage 4 CKD (GFR of 15-29 ml/min) and stage 5 CKD (GFR of <15 ml/min).Group II: 20 patients on maintenance hemodialysis for more than one year They were divided into two subgroups: Group IIa: 10 patients with intact PTH < 300 pg/ml.Group IIb: 10 patients with intact PTH > 300 pg/ml.Group III:10 age and sex matched healthy controls.Investigations will include measurements of Serum calcium,phosphorus, serum alkaline phosphatase,serum intact PTHand Assay of serum osteoprotegerin by enzyme linked immunosorbent assay (ELISA) technique. Results: Serum levels of OPG were higher in patients with CKD and patients on maintenance hemodialysis than healthy control. Serum levels of OPG were significantly higher in stage 4 and 5 CKD than in stage 2 and 3 CKD. Conclusions: Serum OPG level could be of help in the non-invasive diagnosis and monitoring of bone turn over state in patients with CKD.

Published in	American Journal of Internal Medicine (Volume 4, Issue 2-1) This article belongs to the Special Issue Different Medical Research From Middle East
DOI	10.11648/j.ajim.s.2016040201.12
Page(s)	5-12
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Osteoprotegerin, uremic pateints, diagnosing, Bone Disease

References

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APA Style

Mohamed Magdy, Mona Mostafa, Heba Elshair, Hesham Elghoneimy. (2015). Study of Serum Osteoprotegerin Level in Uremic Patients and Its Relation to Renal Bone Disease. American Journal of Internal Medicine, 4(2-1), 5-12. https://doi.org/10.11648/j.ajim.s.2016040201.12

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ACS Style

Mohamed Magdy; Mona Mostafa; Heba Elshair; Hesham Elghoneimy. Study of Serum Osteoprotegerin Level in Uremic Patients and Its Relation to Renal Bone Disease. Am. J. Intern. Med. 2015, 4(2-1), 5-12. doi: 10.11648/j.ajim.s.2016040201.12

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AMA Style

Mohamed Magdy, Mona Mostafa, Heba Elshair, Hesham Elghoneimy. Study of Serum Osteoprotegerin Level in Uremic Patients and Its Relation to Renal Bone Disease. Am J Intern Med. 2015;4(2-1):5-12. doi: 10.11648/j.ajim.s.2016040201.12

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@article{10.11648/j.ajim.s.2016040201.12,
  author = {Mohamed Magdy and Mona Mostafa and Heba Elshair and Hesham Elghoneimy},
  title = {Study of Serum Osteoprotegerin Level in Uremic Patients and Its Relation to Renal Bone Disease},
  journal = {American Journal of Internal Medicine},
  volume = {4},
  number = {2-1},
  pages = {5-12},
  doi = {10.11648/j.ajim.s.2016040201.12},
  url = {https://doi.org/10.11648/j.ajim.s.2016040201.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.s.2016040201.12},
  abstract = {Introduction: Bone disease associated with renal failure is termed renal osteodystrophy and is quite heterogeneous. Microscopic examination of a bone biopsy specimen is still considered the gold standard for diagnosis. Nevertheless, recent studies suggest that serum markers of bone formation and resorption may be of additional help in assessing bone turnover. Osteoprotegerin (OPG) and osteoprotegerin ligand (OPGL) constitute a complex mediator system involved in the regulation of the resorption process in bone. The present work aimed at studying the serum levels of osteoprotegerin and relation of osteoprotegerin to PTH and x-ray features of renal osteodystrophy has been studied. Subjects and methods: The present study was conducted on three groups Group I: 20 patients with chronic kidney disease( CKD) divided into two subgroups: Group Ia: 10 patients in stage 2 CKD (GFR of 60-89 ml/min) and stage 3 CKD (GFR of 30-59 ml/min).Group Ib: 10 patients in stage 4 CKD (GFR of 15-29 ml/min) and stage 5 CKD (GFR of Results: Serum levels of OPG were higher in patients with CKD and patients on maintenance hemodialysis than healthy control. Serum levels of OPG were significantly higher in stage 4 and 5 CKD than in stage 2 and 3 CKD. Conclusions: Serum OPG level could be of help in the non-invasive diagnosis and monitoring of bone turn over state in patients with CKD.},
 year = {2015}
}

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TY  - JOUR
T1  - Study of Serum Osteoprotegerin Level in Uremic Patients and Its Relation to Renal Bone Disease
AU  - Mohamed Magdy
AU  - Mona Mostafa
AU  - Heba Elshair
AU  - Hesham Elghoneimy
Y1  - 2015/10/25
PY  - 2015
N1  - https://doi.org/10.11648/j.ajim.s.2016040201.12
DO  - 10.11648/j.ajim.s.2016040201.12
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 5
EP  - 12
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.s.2016040201.12
AB  - Introduction: Bone disease associated with renal failure is termed renal osteodystrophy and is quite heterogeneous. Microscopic examination of a bone biopsy specimen is still considered the gold standard for diagnosis. Nevertheless, recent studies suggest that serum markers of bone formation and resorption may be of additional help in assessing bone turnover. Osteoprotegerin (OPG) and osteoprotegerin ligand (OPGL) constitute a complex mediator system involved in the regulation of the resorption process in bone. The present work aimed at studying the serum levels of osteoprotegerin and relation of osteoprotegerin to PTH and x-ray features of renal osteodystrophy has been studied. Subjects and methods: The present study was conducted on three groups Group I: 20 patients with chronic kidney disease( CKD) divided into two subgroups: Group Ia: 10 patients in stage 2 CKD (GFR of 60-89 ml/min) and stage 3 CKD (GFR of 30-59 ml/min).Group Ib: 10 patients in stage 4 CKD (GFR of 15-29 ml/min) and stage 5 CKD (GFR of Results: Serum levels of OPG were higher in patients with CKD and patients on maintenance hemodialysis than healthy control. Serum levels of OPG were significantly higher in stage 4 and 5 CKD than in stage 2 and 3 CKD. Conclusions: Serum OPG level could be of help in the non-invasive diagnosis and monitoring of bone turn over state in patients with CKD.
VL  - 4
IS  - 2-1
ER  -

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Author Information

Mohamed Magdy

Internal medicinedepartment, Nephrology unit, Faculty of medicine, Alexandria University, Alexandria, Eygypt
Mona Mostafa

Medical Biochemistrydepartment, Faculty of medicine, Alexandria University, Alexandria, Eygypt
Heba Elshair

Internal medicinedepartment, Nephrology unit, Faculty of medicine, Alexandria University, Alexandria, Eygypt
Hesham Elghoneimy

Internal medicinedepartment, Nephrology unit, Faculty of medicine, Alexandria University, Alexandria, Eygypt

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APA Style

Mohamed Magdy, Mona Mostafa, Heba Elshair, Hesham Elghoneimy. (2015). Study of Serum Osteoprotegerin Level in Uremic Patients and Its Relation to Renal Bone Disease. American Journal of Internal Medicine, 4(2-1), 5-12. https://doi.org/10.11648/j.ajim.s.2016040201.12

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ACS Style

Mohamed Magdy; Mona Mostafa; Heba Elshair; Hesham Elghoneimy. Study of Serum Osteoprotegerin Level in Uremic Patients and Its Relation to Renal Bone Disease. Am. J. Intern. Med. 2015, 4(2-1), 5-12. doi: 10.11648/j.ajim.s.2016040201.12

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AMA Style

Mohamed Magdy, Mona Mostafa, Heba Elshair, Hesham Elghoneimy. Study of Serum Osteoprotegerin Level in Uremic Patients and Its Relation to Renal Bone Disease. Am J Intern Med. 2015;4(2-1):5-12. doi: 10.11648/j.ajim.s.2016040201.12

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@article{10.11648/j.ajim.s.2016040201.12,
  author = {Mohamed Magdy and Mona Mostafa and Heba Elshair and Hesham Elghoneimy},
  title = {Study of Serum Osteoprotegerin Level in Uremic Patients and Its Relation to Renal Bone Disease},
  journal = {American Journal of Internal Medicine},
  volume = {4},
  number = {2-1},
  pages = {5-12},
  doi = {10.11648/j.ajim.s.2016040201.12},
  url = {https://doi.org/10.11648/j.ajim.s.2016040201.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.s.2016040201.12},
  abstract = {Introduction: Bone disease associated with renal failure is termed renal osteodystrophy and is quite heterogeneous. Microscopic examination of a bone biopsy specimen is still considered the gold standard for diagnosis. Nevertheless, recent studies suggest that serum markers of bone formation and resorption may be of additional help in assessing bone turnover. Osteoprotegerin (OPG) and osteoprotegerin ligand (OPGL) constitute a complex mediator system involved in the regulation of the resorption process in bone. The present work aimed at studying the serum levels of osteoprotegerin and relation of osteoprotegerin to PTH and x-ray features of renal osteodystrophy has been studied. Subjects and methods: The present study was conducted on three groups Group I: 20 patients with chronic kidney disease( CKD) divided into two subgroups: Group Ia: 10 patients in stage 2 CKD (GFR of 60-89 ml/min) and stage 3 CKD (GFR of 30-59 ml/min).Group Ib: 10 patients in stage 4 CKD (GFR of 15-29 ml/min) and stage 5 CKD (GFR of Results: Serum levels of OPG were higher in patients with CKD and patients on maintenance hemodialysis than healthy control. Serum levels of OPG were significantly higher in stage 4 and 5 CKD than in stage 2 and 3 CKD. Conclusions: Serum OPG level could be of help in the non-invasive diagnosis and monitoring of bone turn over state in patients with CKD.},
 year = {2015}
}

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TY  - JOUR
T1  - Study of Serum Osteoprotegerin Level in Uremic Patients and Its Relation to Renal Bone Disease
AU  - Mohamed Magdy
AU  - Mona Mostafa
AU  - Heba Elshair
AU  - Hesham Elghoneimy
Y1  - 2015/10/25
PY  - 2015
N1  - https://doi.org/10.11648/j.ajim.s.2016040201.12
DO  - 10.11648/j.ajim.s.2016040201.12
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 5
EP  - 12
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.s.2016040201.12
AB  - Introduction: Bone disease associated with renal failure is termed renal osteodystrophy and is quite heterogeneous. Microscopic examination of a bone biopsy specimen is still considered the gold standard for diagnosis. Nevertheless, recent studies suggest that serum markers of bone formation and resorption may be of additional help in assessing bone turnover. Osteoprotegerin (OPG) and osteoprotegerin ligand (OPGL) constitute a complex mediator system involved in the regulation of the resorption process in bone. The present work aimed at studying the serum levels of osteoprotegerin and relation of osteoprotegerin to PTH and x-ray features of renal osteodystrophy has been studied. Subjects and methods: The present study was conducted on three groups Group I: 20 patients with chronic kidney disease( CKD) divided into two subgroups: Group Ia: 10 patients in stage 2 CKD (GFR of 60-89 ml/min) and stage 3 CKD (GFR of 30-59 ml/min).Group Ib: 10 patients in stage 4 CKD (GFR of 15-29 ml/min) and stage 5 CKD (GFR of Results: Serum levels of OPG were higher in patients with CKD and patients on maintenance hemodialysis than healthy control. Serum levels of OPG were significantly higher in stage 4 and 5 CKD than in stage 2 and 3 CKD. Conclusions: Serum OPG level could be of help in the non-invasive diagnosis and monitoring of bone turn over state in patients with CKD.
VL  - 4
IS  - 2-1
ER  -

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